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1989 1
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Page 1
[Crystalline modifications and polymorphism changes during drug manufacture].
Doelker E. Doelker E. Ann Pharm Fr. 2002 May;60(3):161-76. Ann Pharm Fr. 2002. PMID: 12050595 Review. French.
More than half of the pharmaceutical compounds exhibit polymorphism or pseudopolymorphism, e.g., they exist as more than one crystalline structure (true polymorphs, hydrates, solvates) or as more or less amorphous products. ...
More than half of the pharmaceutical compounds exhibit polymorphism or pseudopolymorphism, e.g., they exist as more than one crystall …
Intra-articular bioactivity of a p38 MAPK inhibitor and development of an extended-release system.
Pradal J, Zuluaga MF, Maudens P, Waldburger JM, Seemayer CA, Doelker E, Gabay C, Jordan O, Allémann E. Pradal J, et al. Eur J Pharm Biopharm. 2015 Jun;93:110-7. doi: 10.1016/j.ejpb.2015.03.017. Epub 2015 Mar 30. Eur J Pharm Biopharm. 2015. PMID: 25836052
The in vitro bioactivity of VX-745 was also shown on synoviocytes, reducing the IL-6 concentration. Process and formulation parameters (i.e., polymer concentration, aqueous/organic phase ratio, emulsification speed and process, and evaporation pressure) and particle charac …
The in vitro bioactivity of VX-745 was also shown on synoviocytes, reducing the IL-6 concentration. Process and formulation parameters (i. …
Development of a nanoprecipitation method intended for the entrapment of hydrophilic drugs into nanoparticles.
Bilati U, Allémann E, Doelker E. Bilati U, et al. Eur J Pharm Sci. 2005 Jan;24(1):67-75. doi: 10.1016/j.ejps.2004.09.011. Eur J Pharm Sci. 2005. PMID: 15626579
This study investigates formulation and process modifications to improve the versatility of the nanoprecipitation technique, particularly with respect to the encapsulation of hydrophilic drugs (e.g. proteins). More specifically, the principal objective was to explore the i …
This study investigates formulation and process modifications to improve the versatility of the nanoprecipitation technique, particularly wi …
Preparation of surfactant-free nanoparticles of methacrylic acid copolymers used for film coating.
Nguyen CA, Konan-Kouakou YN, Allémann E, Doelker E, Quintanar-Guerrero D, Fessi H, Gurny R. Nguyen CA, et al. AAPS PharmSciTech. 2006 Jul 28;7(3):63. doi: 10.1208/pt070363. AAPS PharmSciTech. 2006. PMID: 17025244 Free PMC article.
In addition, a pseudolatex of Eudragit E was used to validate the coating properties of the formulation for solid dosage forms. ...The dissolution profile of quinidine sulfate from the tablets coated with the Eudragit E pseudolatex was comparable to that of tablets …
In addition, a pseudolatex of Eudragit E was used to validate the coating properties of the formulation for solid dosage forms. ...Th …
An investigation on the role of plasma and serum opsonins on the internalization of biodegradable poly(D,L-lactic acid) nanoparticles by human monocytes.
Leroux JC, De Jaeghere F, Anner B, Doelker E, Gurny R. Leroux JC, et al. Life Sci. 1995;57(7):695-703. doi: 10.1016/0024-3205(95)00321-v. Life Sci. 1995. PMID: 7637541
We suggest that typical plasma proteins, heat labile serum proteins (e.g. complement components) and IgG are involved in the opsonization of plain and coated PLA NP. Other proteins previously found to adsorb onto these NP, namely albumin and apolipoprotein E, did no …
We suggest that typical plasma proteins, heat labile serum proteins (e.g. complement components) and IgG are involved in the opsoniza …
Adaptation and optimization of the emulsification-diffusion technique to prepare lipidic nanospheres.
Quintanar-Guerrero D, Tamayo-Esquivel D, Ganem-Quintanar A, Allémann E, Doelker E. Quintanar-Guerrero D, et al. Eur J Pharm Sci. 2005 Oct;26(2):211-8. doi: 10.1016/j.ejps.2005.06.001. Eur J Pharm Sci. 2005. PMID: 16046105
This new approach for the preparation of LN has clear advantages over the existing methods, namely: (i) it is efficient and versatile; (ii) easy implementation and scaling up (with no need of high energy sources); (iii) high reproducibility and narrow size distribution; (iv) less …
This new approach for the preparation of LN has clear advantages over the existing methods, namely: (i) it is efficient and versatile; (ii) …
Methodology for a better evaluation of the relation between mechanical strength of solids and polymorphic form.
Kopp S, Beyer C, Graf E, Kubel F, Doelker E. Kopp S, et al. J Pharm Pharmacol. 1989 Feb;41(2):79-82. doi: 10.1111/j.2042-7158.1989.tb06397.x. J Pharm Pharmacol. 1989. PMID: 2568432
In order to evaluate the role played by polymorphism in the mechanical strength of solid dosage forms (e.g. compressed tablets) and minimize the influence of other factors (such as compaction force, porosity, particle size, and possibly crystal habit), a melted disc techno …
In order to evaluate the role played by polymorphism in the mechanical strength of solid dosage forms (e.g. compressed tablets) and m …
Physicochemical parameters associated with nanoparticle formation in the salting-out, emulsification-diffusion, and nanoprecipitation methods.
Galindo-Rodriguez S, Allémann E, Fessi H, Doelker E. Galindo-Rodriguez S, et al. Pharm Res. 2004 Aug;21(8):1428-39. doi: 10.1023/b:pham.0000036917.75634.be. Pharm Res. 2004. PMID: 15359578
CONCLUSIONS: NP formation by salting-out and emulsification-diffusion was related to PVAL chain interactions at the droplet interface (e.g., reduction in the interfacial tension, mechanical stabilization, and steric stabilization) and in the bulk solution (hydrodynamic sta …
CONCLUSIONS: NP formation by salting-out and emulsification-diffusion was related to PVAL chain interactions at the droplet interface (e …
Pseudolatex preparation using a novel emulsion-diffusion process involving direct displacement of partially water-miscible solvents by distillation.
Quintanar-Guerrero D, Allémann E, Fessi H, Doelker E. Quintanar-Guerrero D, et al. Int J Pharm. 1999 Oct 25;188(2):155-64. doi: 10.1016/s0378-5173(99)00216-1. Int J Pharm. 1999. PMID: 10518671
Using this method, it was possible to prepare pseudolatexes of biodegradable and non-biodegradable polymers such as poly(D,L-lactic acid) and poly(epsilon-caprolactone), Eudragit E, cellulose acetate phthalate, cellulose acetate trimellitate using ethyl acetate or 2-butano …
Using this method, it was possible to prepare pseudolatexes of biodegradable and non-biodegradable polymers such as poly(D,L-lactic acid) an …
15 results