Identification of a T follicular helper cell subset that drives anaphylactic IgE.
Gowthaman U, Chen JS, Zhang B, Flynn WF, Lu Y, Song W, Joseph J, Gertie JA, Xu L, Collet MA, Grassmann JDS, Simoneau T, Chiang D, Berin MC, Craft JE, Weinstein JS, Williams A, Eisenbarth SC.
Gowthaman U, et al.
Science. 2019 Aug 30;365(6456):eaaw6433. doi: 10.1126/science.aaw6433. Epub 2019 Aug 1.
Science. 2019.
PMID: 31371561
Free PMC article.
Cross-linking of high-affinity immunoglobulin E (IgE) results in the life-threatening allergic reaction anaphylaxis. Yet the cellular mechanisms that induce B cells to produce IgE in response to allergens remain poorly understood. ...
Cross-linking of high-affinity immunoglobulin E (IgE) results in the life-threatening allergic reaction anaphylaxis. Yet the cellular …