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1901 1
1906 1
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1908 1
1910 1
1914 1
1919 1
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35,102 results

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The following term was not found in PubMed: Dorin-Dacian
Page 1
The let-7 family of microRNAs.
Roush S, Slack FJ. Roush S, et al. Trends Cell Biol. 2008 Oct;18(10):505-16. doi: 10.1016/j.tcb.2008.07.007. Epub 2008 Sep 4. Trends Cell Biol. 2008. PMID: 18774294 Review.
Although much research has been devoted to let-7 target prediction and to understanding its biological role, research into what regulates let-7 has only just begun. Here, we review let-7-family conservation and the recent advances in understanding how let …
Although much research has been devoted to let-7 target prediction and to understanding its biological role, research into what regul …
Function and regulation of let-7 family microRNAs.
Su JL, Chen PS, Johansson G, Kuo ML. Su JL, et al. Microrna. 2012;1(1):34-9. doi: 10.2174/2211536611201010034. Microrna. 2012. PMID: 25048088 Review.
Furthermore, there is a large body of evidence linking the loss of let-7 expression and the development of poorly differentiated, aggressive cancers. ...Moreover, the direct interaction between miRNAs has recently been identified as a novel pathway to control let-7 …
Furthermore, there is a large body of evidence linking the loss of let-7 expression and the development of poorly differentiated, agg …
Lateral elbow tendinopathy: Evidence of physiotherapy management.
Dimitrios S. Dimitrios S. World J Orthop. 2016 Aug 18;7(8):463-6. doi: 10.5312/wjo.v7.i8.463. eCollection 2016 Aug 18. World J Orthop. 2016. PMID: 27622145 Free PMC article.
Lateral elbow tendinopathy (LET) is a common musculoskeletal/sports injury. A plethora of physiotherapy techniques has been proposed in the management of LET. The exercise programme is the most common treatment in the management of LET. The optimal protocol o …
Lateral elbow tendinopathy (LET) is a common musculoskeletal/sports injury. A plethora of physiotherapy techniques has been proposed …
The LIN28/let-7 Pathway in Cancer.
Balzeau J, Menezes MR, Cao S, Hagan JP. Balzeau J, et al. Front Genet. 2017 Mar 28;8:31. doi: 10.3389/fgene.2017.00031. eCollection 2017. Front Genet. 2017. PMID: 28400788 Free PMC article. Review.
Activation of either LIN28A or LIN28B, two highly related RNA binding proteins (RBPs) and proto-oncogenes, is responsible for the global post-transcriptional downregulation of the let-7 microRNA family observed in many cancers. Specifically, LIN28A binds the terminal loop …
Activation of either LIN28A or LIN28B, two highly related RNA binding proteins (RBPs) and proto-oncogenes, is responsible for the global pos …
Dual mechanism of Let-7i in tumor progression.
Zhou J, Xiang H, Cao Z. Zhou J, et al. Front Oncol. 2023 Sep 27;13:1253191. doi: 10.3389/fonc.2023.1253191. eCollection 2023. Front Oncol. 2023. PMID: 37829341 Free PMC article. Review.
Let-7i also has an epigenetic function via modulating DNA methylation to directly regulate gene expression. Let-7i performs a dual role by inducing both the promotion and inhibition of various malignancies, depending on its target. ...
Let-7i also has an epigenetic function via modulating DNA methylation to directly regulate gene expression. Let-7i performs a …
Computational models and tools.
Schuemann J, Bassler N, Inaniwa T. Schuemann J, et al. Med Phys. 2018 Nov;45(11):e1073-e1085. doi: 10.1002/mp.12521. Med Phys. 2018. PMID: 30421814 Review.
We discuss the difference between the prescribed physical dose and the biologically effective dose, the relative biological effectiveness (RBE) between ions and photons and the dependence of RBE on the linear energy transfer (LET). Lastly, we show how LET- or RBE-ba …
We discuss the difference between the prescribed physical dose and the biologically effective dose, the relative biological effectiveness (R …
Crohn's disease-associated AIEC inhibiting intestinal epithelial cell-derived exosomal let-7b expression regulates macrophage polarization to exacerbate intestinal fibrosis.
Xu Y, Qian W, Huang L, Wen W, Li Y, Guo F, Zhu Z, Li Z, Gong J, Yu Z, Zhou Y, Lu N, Zhu W, Guo Z. Xu Y, et al. Gut Microbes. 2023 Jan-Dec;15(1):2193115. doi: 10.1080/19490976.2023.2193115. Gut Microbes. 2023. PMID: 36945126 Free PMC article.
Besides, AIEC-infected IL-10(-/-) mice presented more severe intestinal fibrosis and could be improved by exogenous let-7b. Mechanistically, intestinal macrophages were found to be the main target of let-7b. ...In vitro, AIEC suppressed exosomal let-7b derive …
Besides, AIEC-infected IL-10(-/-) mice presented more severe intestinal fibrosis and could be improved by exogenous let-7b. Mechanist …
Biogenesis and regulation of the let-7 miRNAs and their functional implications.
Lee H, Han S, Kwon CS, Lee D. Lee H, et al. Protein Cell. 2016 Feb;7(2):100-13. doi: 10.1007/s13238-015-0212-y. Epub 2015 Sep 23. Protein Cell. 2016. PMID: 26399619 Free PMC article. Review.
Unlike in C. elegans, higher animals have multiple isoforms of let-7 miRNAs; these isoforms share a consensus sequence called the 'seed sequence' and these isoforms are categorized into let-7 miRNA family. ...Because dysregulation of let-7 processing is delet …
Unlike in C. elegans, higher animals have multiple isoforms of let-7 miRNAs; these isoforms share a consensus sequence called the 'se …
Role of let-7 family microRNA in breast cancer.
Thammaiah CK, Jayaram S. Thammaiah CK, et al. Noncoding RNA Res. 2016 Nov 4;1(1):77-82. doi: 10.1016/j.ncrna.2016.10.003. eCollection 2016 Oct. Noncoding RNA Res. 2016. PMID: 30159414 Free PMC article. Review.
We discussed the mechanism by which let-7 alter the expression of genes involved in the process of tumorigenesis. Further, we listed the pathways targeted by let-7 to reduce the burden of the tumor. In addition, we described the role of let-7 in breast cancer …
We discussed the mechanism by which let-7 alter the expression of genes involved in the process of tumorigenesis. Further, we listed …
Cataractogenesis following high-LET radiation exposure.
Hamada N, Sato T. Hamada N, et al. Mutat Res Rev Mutat Res. 2016 Oct-Dec;770(Pt B):262-291. doi: 10.1016/j.mrrev.2016.08.005. Epub 2016 Aug 20. Mutat Res Rev Mutat Res. 2016. PMID: 27919335 Review.
Biological effectiveness of ionizing radiation differs with its linear energy transfer (LET) such that high-LET radiation is more effective for various biological endpoints than low-LET radiation. ...Considering such radiosensitive nature of the lens, a deepe …
Biological effectiveness of ionizing radiation differs with its linear energy transfer (LET) such that high-LET radiation is m …
35,102 results
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