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Centyrin ligands for extrahepatic delivery of siRNA.
Klein D, Goldberg S, Theile CS, Dambra R, Haskell K, Kuhar E, Lin T, Parmar R, Manoharan M, Richter M, Wu M, Mendrola Zarazowski J, Jadhav V, Maier MA, Sepp-Lorenzino L, O'Neil K, Dudkin V. Klein D, et al. Mol Ther. 2021 Jun 2;29(6):2053-2066. doi: 10.1016/j.ymthe.2021.02.015. Epub 2021 Feb 15. Mol Ther. 2021. PMID: 33601052 Free PMC article.
Engineering a targeted delivery platform using Centyrins.
Goldberg SD, Cardoso RM, Lin T, Spinka-Doms T, Klein D, Jacobs SA, Dudkin V, Gilliland G, O'Neil KT. Goldberg SD, et al. Among authors: klein d. Protein Eng Des Sel. 2016 Dec;29(12):563-572. doi: 10.1093/protein/gzw054. Epub 2016 Oct 13. Protein Eng Des Sel. 2016. PMID: 27737926
Trastuzumab-MMAU Antibody-Auristatin Conjugates: Valine-Glucoserine Linker with Stabilized Maleimide Conjugation Improves In Vivo Efficacy and Tolerability.
Goldberg SD, Satomaa T, Aina O, Aitio O, Burke K, Dudkin V, Geist B, Irrechukwu O, Hänninen AL, Heiskanen A, Helin J, Hiltunen JO, Kinyamu-Akunda J, Klein DM, Kohli N, Kotiranta T, Lähteenmäki T, Niemelä R, Pitkänen V, Pynnönen H, Rittase W, Wiley K, Zhou J, Saarinen J. Goldberg SD, et al. Among authors: klein dm. Mol Cancer Ther. 2024 Feb 7. doi: 10.1158/1535-7163.MCT-23-0591. Online ahead of print. Mol Cancer Ther. 2024. PMID: 38324296