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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1933 1
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1949 2
1950 7
1951 5
1952 2
1953 1
1954 3
1955 17
1956 21
1957 21
1958 23
1959 14
1960 9
1961 7
1962 21
1963 61
1964 42
1965 28
1966 38
1967 16
1968 34
1969 24
1970 31
1971 32
1972 36
1973 43
1974 32
1975 56
1976 61
1977 60
1978 63
1979 94
1980 98
1981 88
1982 97
1983 135
1984 110
1985 135
1986 153
1987 183
1988 205
1989 298
1990 404
1991 344
1992 511
1993 506
1994 570
1995 576
1996 1188
1997 2204
1998 1963
1999 3067
2000 4484
2001 6535
2002 7634
2003 8688
2004 9123
2005 9439
2006 8600
2007 9706
2008 10501
2009 11170
2010 12094
2011 11959
2012 12000
2013 13281
2014 16119
2015 18331
2016 19798
2017 19986
2018 20524
2019 20850
2020 23428
2021 25734
2022 24048
2023 22049
2024 10142

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326,054 results

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The following term was not found in PubMed: Dong-Gyun
Page 1
Did you mean song hyun kyu (106 results)?
The pendulum of the Ku-Ku clock.
Shibata A, Jeggo P, Löbrich M. Shibata A, et al. DNA Repair (Amst). 2018 Nov;71:164-171. doi: 10.1016/j.dnarep.2018.08.020. Epub 2018 Aug 23. DNA Repair (Amst). 2018. PMID: 30177438 Free article. Review.
Emerging evidence has suggested that Ku is the first protein binding most, if not all, DSBs, and creates a block to resection. ...Our review reveals that Ku plays an active role in determining pathway choice and exposes similarities yet distinctions in the progressi …
Emerging evidence has suggested that Ku is the first protein binding most, if not all, DSBs, and creates a block to resection. ...Our …
Anti-Ku-positive juvenile dermatomyositis.
Cotter C, Rudd E, Williamson E, Philippidou M, Tewari A. Cotter C, et al. Clin Exp Dermatol. 2022 Feb;47(2):425-427. doi: 10.1111/ced.14937. Epub 2021 Oct 8. Clin Exp Dermatol. 2022. PMID: 34528293 No abstract available.
Plugged into the Ku-DNA hub: The NHEJ network.
Frit P, Ropars V, Modesti M, Charbonnier JB, Calsou P. Frit P, et al. Prog Biophys Mol Biol. 2019 Oct;147:62-76. doi: 10.1016/j.pbiomolbio.2019.03.001. Epub 2019 Mar 6. Prog Biophys Mol Biol. 2019. PMID: 30851288 Review.
Through protein-protein contacts eventually reinforced by protein-DNA interactions, the Ku-DNA hub attracts a series of specialized proteins with scaffolding and/or enzymatic properties. To shed light on these dynamic interplays, we review here current knowledge on protein …
Through protein-protein contacts eventually reinforced by protein-DNA interactions, the Ku-DNA hub attracts a series of specialized p …
The Multifaceted Roles of Ku70/80.
Zahid S, Seif El Dahan M, Iehl F, Fernandez-Varela P, Le Du MH, Ropars V, Charbonnier JB. Zahid S, et al. Int J Mol Sci. 2021 Apr 16;22(8):4134. doi: 10.3390/ijms22084134. Int J Mol Sci. 2021. PMID: 33923616 Free PMC article. Review.
Understanding the molecular basis of c-NHEJ has major outcomes in several fields, including radiobiology, cancer therapy, immune disease, and genome editing. The heterodimer Ku70/80 (Ku) is a central actor of the c-NHEJ as it rapidly recognizes broken DNA ends in the cell …
Understanding the molecular basis of c-NHEJ has major outcomes in several fields, including radiobiology, cancer therapy, immune disease, an …
The Ku complex: recent advances and emerging roles outside of non-homologous end-joining.
Abbasi S, Parmar G, Kelly RD, Balasuriya N, Schild-Poulter C. Abbasi S, et al. Cell Mol Life Sci. 2021 May;78(10):4589-4613. doi: 10.1007/s00018-021-03801-1. Epub 2021 Apr 15. Cell Mol Life Sci. 2021. PMID: 33855626 Free PMC article. Review.
Some advances have been driven by clarification of Ku's structure, including the original Ku crystal structure and the more recent Ku-DNA-PK(cs) crystallography, cryogenic electron microscopy (cryoEM) studies, and the identification of various post-translatio …
Some advances have been driven by clarification of Ku's structure, including the original Ku crystal structure and the more re …
Noncanonical functions of Ku may underlie essentiality in human cells.
Kelly RD, Parmar G, Bayat L, Maitland MER, Lajoie GA, Edgell DR, Schild-Poulter C. Kelly RD, et al. Sci Rep. 2023 Jul 27;13(1):12162. doi: 10.1038/s41598-023-39166-7. Sci Rep. 2023. PMID: 37500706 Free PMC article.
Here, we established conditional Ku70 knockout cells using CRISPR/Cas9 editing to study the essentiality of Ku70 function. While we observed loss of cell viability upon Ku depletion, we did not detect significant changes in telomere length, nor did we record lethal levels …
Here, we established conditional Ku70 knockout cells using CRISPR/Cas9 editing to study the essentiality of Ku70 function. While we observed …
The Ku heterodimer: function in DNA repair and beyond.
Fell VL, Schild-Poulter C. Fell VL, et al. Mutat Res Rev Mutat Res. 2015 Jan-Mar;763:15-29. doi: 10.1016/j.mrrev.2014.06.002. Epub 2014 Jul 4. Mutat Res Rev Mutat Res. 2015. PMID: 25795113 Review.
Ku also functions to prevent tumorigenesis and senescence since Ku-deficient mice show increased cancer incidence and early onset of aging. Overall, Ku function is critical to the maintenance of genomic integrity and to proper cellular and organismal developm …
Ku also functions to prevent tumorigenesis and senescence since Ku-deficient mice show increased cancer incidence and early on …
RNA:DNA hybrids from Okazaki fragments contribute to establish the Ku-mediated barrier to replication-fork degradation.
Audoynaud C, Schirmeisen K, Ait Saada A, Gesnik A, Fernández-Varela P, Boucherit V, Ropars V, Chaudhuri A, Fréon K, Charbonnier JB, Lambert SAE. Audoynaud C, et al. Mol Cell. 2023 Apr 6;83(7):1061-1074.e6. doi: 10.1016/j.molcel.2023.02.008. Epub 2023 Mar 2. Mol Cell. 2023. PMID: 36868227 Free article.
Mechanistically, the need of RNaseH2 in nascent strand degradation requires the primase activity that allows establishing the Ku barrier to Exo1, whereas impairing Okazaki fragment maturation reinforces the Ku barrier. Finally, replication stress induces Ku f …
Mechanistically, the need of RNaseH2 in nascent strand degradation requires the primase activity that allows establishing the Ku barr …
Ku: a multifunctional protein involved in telomere maintenance.
Fisher TS, Zakian VA. Fisher TS, et al. DNA Repair (Amst). 2005 Nov 21;4(11):1215-26. doi: 10.1016/j.dnarep.2005.04.021. Epub 2005 Jun 24. DNA Repair (Amst). 2005. PMID: 15979949 Review.
Paradoxically, while Ku is required for double-stranded break repair by non-homologous end-joining, in many organisms, Ku is also associated with telomeres. ...Here, we review the role of Ku at telomeres in the model organism, Saccharomyces cerevisiae and com …
Paradoxically, while Ku is required for double-stranded break repair by non-homologous end-joining, in many organisms, Ku is a …
The Ku complex promotes DNA end-bridging and this function is antagonized by Tel1/ATM kinase.
Rinaldi C, Pizzul P, Casari E, Mangiagalli M, Tisi R, Longhese MP. Rinaldi C, et al. Nucleic Acids Res. 2023 Feb 28;51(4):1783-1802. doi: 10.1093/nar/gkad062. Nucleic Acids Res. 2023. PMID: 36762474 Free PMC article.
Impairing histone removal around DSBs either by eliminating Tel1 kinase activity or nucleosome remodelers enhances Ku persistence at DSBs and DSB bridging, suggesting that Tel1 antagonizes the Ku function in supporting end-tethering by promoting nucleosome removal a …
Impairing histone removal around DSBs either by eliminating Tel1 kinase activity or nucleosome remodelers enhances Ku persistence at …
326,054 results
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