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Page 1
Did you mean dong wu (982 results)?
Emerging phagocytosis checkpoints in cancer immunotherapy.
Liu Y, Wang Y, Yang Y, Weng L, Wu Q, Zhang J, Zhao P, Fang L, Shi Y, Wang P. Liu Y, et al. Signal Transduct Target Ther. 2023 Mar 7;8(1):104. doi: 10.1038/s41392-023-01365-z. Signal Transduct Target Ther. 2023. PMID: 36882399 Free PMC article. Review.
Phagocytosis checkpoints, such as CD47, CD24, MHC-I, PD-L1, STC-1 and GD2, have emerged as essential checkpoints for cancer immunotherapy by functioning as "don't eat me" signals or interacting with "eat me" signals to suppress immune responses. ...
Phagocytosis checkpoints, such as CD47, CD24, MHC-I, PD-L1, STC-1 and GD2, have emerged as essential checkpoints for cancer immunotherapy by …
Bergenia pacumbis (Buch.-Ham. ex D.Don) C.Y.Wu & J.T.Pan: A Comprehensive Review on Traditional Uses, Phytochemistry and Pharmacology.
Gohain A, Sharma A, Gogoi HJ, Cooper R, Kaur R, Nayik GA, Shaikh AM, Kovács B, Areche FO, Ansari MJ, Alabdallah NM, Al-Farga A. Gohain A, et al. Plants (Basel). 2022 Apr 21;11(9):1129. doi: 10.3390/plants11091129. Plants (Basel). 2022. PMID: 35567130 Free PMC article. Review.
Nature has produced an immense number of medicinal plants, which directly or indirectly help to treat various ailments and have numerous applications in the fields of pharmaceuticals, agriculture, food flavors and preservatives, aromas, and cosmetics. Bergenia pacumbis (Buch.-Ham …
Nature has produced an immense number of medicinal plants, which directly or indirectly help to treat various ailments and have numerous app …
Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug.
Rais R, Lemberg KM, Tenora L, Arwood ML, Pal A, Alt J, Wu Y, Lam J, Aguilar JMH, Zhao L, Peters DE, Tallon C, Pandey R, Thomas AG, Dash RP, Seiwert T, Majer P, Leone RD, Powell JD, Slusher BS. Rais R, et al. Sci Adv. 2022 Nov 18;8(46):eabq5925. doi: 10.1126/sciadv.abq5925. Epub 2022 Nov 16. Sci Adv. 2022. PMID: 36383674 Free PMC article.
DON showed promising efficacy in clinical trials; however, its development was halted by dose-limiting gastrointestinal (GI) toxicities. Given its clinical potential, we designed DON peptide prodrugs and found DRP-104 [isopropyl(S)-2-((S)-2-acetamido-3-(1H-indol-3-y …
DON showed promising efficacy in clinical trials; however, its development was halted by dose-limiting gastrointestinal (GI) toxiciti …
Responsive Exosome Nano-bioconjugates for Synergistic Cancer Therapy.
Nie W, Wu G, Zhang J, Huang LL, Ding J, Jiang A, Zhang Y, Liu Y, Li J, Pu K, Xie HY. Nie W, et al. Angew Chem Int Ed Engl. 2020 Jan 27;59(5):2018-2022. doi: 10.1002/anie.201912524. Epub 2019 Dec 18. Angew Chem Int Ed Engl. 2020. PMID: 31746532
In the acidic tumor microenvironment, the benzoic-imine bonds of the nano-bioconjugates are cleaved to release aSIRPalpha and aCD47 that can, respectively, block SIRPalpha on macrophages and CD47, leading to abolished "don't eat me" signaling and improved phagocytosis of m …
In the acidic tumor microenvironment, the benzoic-imine bonds of the nano-bioconjugates are cleaved to release aSIRPalpha and aCD47 that can …
The implications for urological malignancies of non-coding RNAs in the the tumor microenvironment.
Wang S, Qi X, Liu D, Xie D, Jiang B, Wang J, Wang X, Wu G. Wang S, et al. Comput Struct Biotechnol J. 2023 Dec 20;23:491-505. doi: 10.1016/j.csbj.2023.12.016. eCollection 2024 Dec. Comput Struct Biotechnol J. 2023. PMID: 38249783 Free PMC article. Review.
Recent studies have highlighted the importance of non-coding RNAs (ncRNAs) - these don't code for proteins but are crucial in controlling genes - and the tumor microenvironment (TME), which is no longer seen as just a background factor but as an active player in cancer pro …
Recent studies have highlighted the importance of non-coding RNAs (ncRNAs) - these don't code for proteins but are crucial in control …
Discovery of a novel dual-targeting D-peptide to block CD24/Siglec-10 and PD-1/PD-L1 interaction and synergize with radiotherapy for cancer immunotherapy.
Shen W, Shi P, Dong Q, Zhou X, Chen C, Sui X, Tian W, Zhu X, Wang X, Jin S, Wu Y, Chen G, Qiu L, Zhai W, Gao Y. Shen W, et al. J Immunother Cancer. 2023 Jun;11(6):e007068. doi: 10.1136/jitc-2023-007068. J Immunother Cancer. 2023. PMID: 37344099 Free PMC article.
BACKGROUND: Aside from immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1), intervention of CD47/Sirpalpha mediated 'don't eat me' signal between macrophage and tumor cell is considered as a promising therapeu …
BACKGROUND: Aside from immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1), …
Deoxynivalenol: Emerging Toxic Mechanisms and Control Strategies, Current and Future Perspectives.
Deng Y, You L, Wang X, Wu W, Kuca K, Wu Q, Wei W. Deng Y, et al. J Agric Food Chem. 2023 Jul 26;71(29):10901-10915. doi: 10.1021/acs.jafc.3c02020. Epub 2023 Jul 12. J Agric Food Chem. 2023. PMID: 37437258 Review.
Noncoding RNA and signaling pathways including Wnt/beta-catenin, FOXO, and TLR4/NF-kappaB also participate in DON toxicity. The intestinal microbiota and the brain-gut axis play a crucial role in DON-induced growth inhibition. In view of the synergistic toxic effect …
Noncoding RNA and signaling pathways including Wnt/beta-catenin, FOXO, and TLR4/NF-kappaB also participate in DON toxicity. The intes …
Quercetin Alleviates Deoxynivalenol-Induced Intestinal Damage by Suppressing Inflammation and Ferroptosis in Mice.
Ye Y, Jiang M, Hong X, Fu Y, Chen Y, Wu H, Sun Y, Wang X, Zhou E, Wang J, Yang Z. Ye Y, et al. J Agric Food Chem. 2023 Jul 19;71(28):10761-10772. doi: 10.1021/acs.jafc.3c02027. Epub 2023 Jul 1. J Agric Food Chem. 2023. PMID: 37392437
In this research, we investigated the potential function of QUE as a treatment for DON-induced intestinal damage. Thirty male specific-pathogen-free BALB/c mice were randomly allocated to treatment with QUE (50 mg/kg) and/or DON (0, 0.5, 1, and 2 mg/kg). ...In this …
In this research, we investigated the potential function of QUE as a treatment for DON-induced intestinal damage. Thirty male specifi …
Nonmotor Symptoms of Parkinson's Disease.
Wu SL, Liscic RM, Kim S, Sorbi S, Yang YH. Wu SL, et al. Parkinsons Dis. 2017;2017:4382518. doi: 10.1155/2017/4382518. Epub 2017 Mar 2. Parkinsons Dis. 2017. PMID: 28352489 Free PMC article. No abstract available.
619 results