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Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO.
de la Fuente-Alonso A, Toral M, Alfayate A, Ruiz-Rodríguez MJ, Bonzón-Kulichenko E, Teixido-Tura G, Martínez-Martínez S, Méndez-Olivares MJ, López-Maderuelo D, González-Valdés I, Garcia-Izquierdo E, Mingo S, Martín CE, Muiño-Mosquera L, De Backer J, Nistal JF, Forteza A, Evangelista A, Vázquez J, Campanero MR, Redondo JM. de la Fuente-Alonso A, et al. Among authors: lopez maderuelo d. Nat Commun. 2021 May 11;12(1):2628. doi: 10.1038/s41467-021-22933-3. Nat Commun. 2021. PMID: 33976159 Free PMC article.
Versican accumulation drives Nos2 induction and aortic disease in Marfan syndrome via Akt activation.
Ruiz-Rodríguez MJ, Oller J, Martínez-Martínez S, Alarcón-Ruiz I, Toral M, Sun Y, Colmenar Á, Méndez-Olivares MJ, López-Maderuelo D, Kern CB, Nistal JF, Evangelista A, Teixido-Tura G, Campanero MR, Redondo JM. Ruiz-Rodríguez MJ, et al. Among authors: lopez maderuelo d. EMBO Mol Med. 2024 Jan;16(1):132-157. doi: 10.1038/s44321-023-00009-7. Epub 2024 Jan 2. EMBO Mol Med. 2024. PMID: 38177536 Free PMC article.
The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis.
Gómez-Del Arco P, Perdiguero E, Yunes-Leites PS, Acín-Pérez R, Zeini M, Garcia-Gomez A, Sreenivasan K, Jiménez-Alcázar M, Segalés J, López-Maderuelo D, Ornés B, Jiménez-Borreguero LJ, D'Amato G, Enshell-Seijffers D, Morgan B, Georgopoulos K, Islam AB, Braun T, de la Pompa JL, Kim J, Enriquez JA, Ballestar E, Muñoz-Cánoves P, Redondo JM. Gómez-Del Arco P, et al. Among authors: lopez maderuelo d. Cell Metab. 2016 May 10;23(5):881-92. doi: 10.1016/j.cmet.2016.04.008. Cell Metab. 2016. PMID: 27166947 Free article.
Selective inhibition of plasma membrane calcium ATPase 4 improves angiogenesis and vascular reperfusion.
Kurusamy S, López-Maderuelo D, Little R, Cadagan D, Savage AM, Ihugba JC, Baggott RR, Rowther FB, Martínez-Martínez S, Arco PG, Murcott C, Wang W, Francisco Nistal J, Oceandy D, Neyses L, Wilkinson RN, Cartwright EJ, Redondo JM, Armesilla AL. Kurusamy S, et al. Among authors: lopez maderuelo d. J Mol Cell Cardiol. 2017 Aug;109:38-47. doi: 10.1016/j.yjmcc.2017.07.001. Epub 2017 Jul 3. J Mol Cell Cardiol. 2017. PMID: 28684310
Plasma membrane calcium ATPase isoform 4 inhibits vascular endothelial growth factor-mediated angiogenesis through interaction with calcineurin.
Baggott RR, Alfranca A, López-Maderuelo D, Mohamed TM, Escolano A, Oller J, Ornes BC, Kurusamy S, Rowther FB, Brown JE, Oceandy D, Cartwright EJ, Wang W, Gómez-del Arco P, Martínez-Martínez S, Neyses L, Redondo JM, Armesilla AL. Baggott RR, et al. Among authors: lopez maderuelo d. Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2310-20. doi: 10.1161/ATVBAHA.114.304363. Epub 2014 Aug 21. Arterioscler Thromb Vasc Biol. 2014. PMID: 25147342
Impact of left ventricular hypertrophy on troponin release during acute myocardial infarction: new insights from a comprehensive translational study.
Fernández-Jiménez R, Silva J, Martínez-Martínez S, López-Maderuelo MD, Nuno-Ayala M, García-Ruiz JM, García-Álvarez A, Fernández-Friera L, Pizarro TG, García-Prieto J, Sanz-Rosa D, López-Martin G, Fernández-Ortiz A, Macaya C, Fuster V, Redondo JM, Ibanez B. Fernández-Jiménez R, et al. Among authors: lopez maderuelo md. J Am Heart Assoc. 2015 Jan 21;4(1):e001218. doi: 10.1161/JAHA.114.001218. J Am Heart Assoc. 2015. PMID: 25609414 Free PMC article.