Synthesis and Preclinical Evaluation of Urea-Based Prostate-Specific Membrane Antigen-Targeted Conjugates Labeled with 177Lu.
Machulkin AE, Petrov SA, Bodenko V, Larkina MS, Plotnikov E, Yuldasheva F, Tretyakova M, Bezverkhniaia E, Zyk NY, Stasyuk E, Zelchan R, Majouga AG, Tolmachev V, Orlova A, Beloglazkina EK, Yusubov MS.
Machulkin AE, et al.
ACS Pharmacol Transl Sci. 2024 May 1;7(5):1457-1473. doi: 10.1021/acsptsci.4c00070. eCollection 2024 May 10.
ACS Pharmacol Transl Sci. 2024.
PMID: 38751647
The [(177)Lu]Lu-13C with the bromine substituent was characterized by the highest activity accumulation in blood, salivary glands, muscle, bone, and gastrointestinal tract and had inasmuch as an unfavorable pharmacokinetic profile. ...
The [(177)Lu]Lu-13C with the bromine substituent was characterized by the highest activity accumulation in blood, salivary glands, mu …