Improved synthesis of substituted 6,7-dihydroxy-4-quinazolineamines: tandutinib, erlotinib and gefitinib

Petr Knesl; Dirk Röseling; Ulrich Jordis

doi:10.3390/11040286

Improved synthesis of substituted 6,7-dihydroxy-4-quinazolineamines: tandutinib, erlotinib and gefitinib

Molecules. 2006 Apr 10;11(4):286-97. doi: 10.3390/11040286.

Authors

Petr Knesl¹, Dirk Röseling, Ulrich Jordis

Affiliation

¹ Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9, 1060 Vienna, Austria.

Abstract

The synthesis of three substituted 6,7-dihydroxy-4-quinazolineamines: tandutinib (1), erlotinib (2) and gefitinib (3) in improved yields is reported. The intermediates were characterized by NMR and the purities determined by HPLC.

MeSH terms

Chromatography, High Pressure Liquid
Erlotinib Hydrochloride
Gefitinib
Magnetic Resonance Spectroscopy
Piperazines / chemical synthesis*
Protein Kinase Inhibitors / chemical synthesis*
Quinazolines / chemical synthesis*

Substances

Piperazines
Protein Kinase Inhibitors
Quinazolines
Erlotinib Hydrochloride
tandutinib
Gefitinib