Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids

Duan Dongfeng; Chen An; Peng Shujia; Yin Jikai; Yang Tao; Dong Rui; Tan Kai; Chen Yafeng; Lu Jianguo; Du Xilin

doi:10.4314/ahs.v14i4.22

Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids

Afr Health Sci. 2014 Dec;14(4):925-8. doi: 10.4314/ahs.v14i4.22.

Authors

Duan Dongfeng¹, Chen An¹, Peng Shujia¹, Yin Jikai¹, Yang Tao¹, Dong Rui¹, Tan Kai¹, Chen Yafeng¹, Lu Jianguo¹, Du Xilin¹

Affiliation

¹ Department of general surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, PR China.

Abstract

Background: The colon plays a key role in regulating the homeostasis of bile acids.

Aim: The present study aims to evaluate the influence of colon cancer towards the homeostasis of bile acids.

Methods: The free and conjugated bile acids were determined using ultraperformance LC (UPLC) coupled with ABI 4000 QTRAP triple quadrupole instruments.

Results: The results showed that the free bile acids in serum of patients with colon cancers tend to increase, and the conjugated bile acids tended to decrease, especially for taurolithocholate (TLCA) (p<0.001).

Conclusion: The alteration of bile acids balance in colon cancers indicated the possibility of complicated diseases due to the disrupted balance of bile acids.

Keywords: Colon cancer; conjugated bile acids; free bile acids.

Publication types

Evaluation Study

MeSH terms

Aged
Bile Acids and Salts / blood*
Case-Control Studies
Chromatography, High Pressure Liquid / methods
Colonic Neoplasms / blood
Colonic Neoplasms / physiopathology*
Female
Homeostasis / physiology*
Humans
Male
Middle Aged

Substances

Bile Acids and Salts