New heteroarylbenzenesulphonamides as matrix metalloproteinase inhibitors

Bioorg Med Chem Lett. 2004 Mar 8;14(5):1119-21. doi: 10.1016/j.bmcl.2003.12.076.

Abstract

A series of derivatives of 2,4- and 2,5-thiazolyl- or oxazolylbenzenesulphonamides has been prepared and evaluated as potential MMP inhibitors. The thiazole 15b have been found to exhibit MMP-2 and MMP-9 inhibitions higher than reference compounds GI 129471 and CGS 27023A.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzenesulfonamides
  • Matrix Metalloproteinase Inhibitors*
  • Matrix Metalloproteinases / metabolism
  • Protease Inhibitors / chemistry*
  • Protease Inhibitors / pharmacology*
  • Sulfonamides / chemistry*
  • Sulfonamides / pharmacology*

Substances

  • Matrix Metalloproteinase Inhibitors
  • Protease Inhibitors
  • Sulfonamides
  • Matrix Metalloproteinases