Abstract
A series of derivatives of 2,4- and 2,5-thiazolyl- or oxazolylbenzenesulphonamides has been prepared and evaluated as potential MMP inhibitors. The thiazole 15b have been found to exhibit MMP-2 and MMP-9 inhibitions higher than reference compounds GI 129471 and CGS 27023A.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzenesulfonamides
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Matrix Metalloproteinase Inhibitors*
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Matrix Metalloproteinases / metabolism
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Protease Inhibitors / chemistry*
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Protease Inhibitors / pharmacology*
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Sulfonamides / chemistry*
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Sulfonamides / pharmacology*
Substances
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Matrix Metalloproteinase Inhibitors
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Protease Inhibitors
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Sulfonamides
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Matrix Metalloproteinases