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Showing results for ddi hu
Search for Didi Hu instead (1 results)
The anti-HIV-1 activity of chloroquine.
Savarino A, Gennero L, Sperber K, Boelaert JR. Savarino A, et al. J Clin Virol. 2001 Feb;20(3):131-5. doi: 10.1016/s1386-6532(00)00139-6. J Clin Virol. 2001. PMID: 11166661 Review.
Because CQ and HCQ appear to have a novel site of action (i.e. post-transcriptional inhibition of gp120), these drugs may be particularly useful in combination with other anti-retroviral agents (e.g. ZDV, ddI and HU). CONCLUSION: combining these drugs with other ant …
Because CQ and HCQ appear to have a novel site of action (i.e. post-transcriptional inhibition of gp120), these drugs may be particularly us …
Anti-Inflammatory Dietary Diversity and Depressive Symptoms among Older Adults: A Nationwide Cross-Sectional Analysis.
Lv X, Sun S, Wang J, Chen H, Li S, Hu Y, Yu M, Zeng Y, Gao X, Xu Y, Yao Y. Lv X, et al. Nutrients. 2022 Nov 28;14(23):5062. doi: 10.3390/nu14235062. Nutrients. 2022. PMID: 36501094 Free PMC article.
We assessed depressive symptoms using the 10 items of the center for epidemiologic studies depression scale (CES-D-10). Based on the dietary diversity index (DDI) generated by previous studies, we construct two novel indicators: the protein-enriched dietary diversity index …
We assessed depressive symptoms using the 10 items of the center for epidemiologic studies depression scale (CES-D-10). Based on the dietary …
Effect of hydroxyurea and dideoxyinosine on intracellular 3'-deoxyadenosine-5'-triphosphate concentrations in HIV-infected patients.
Bakshi RP, Hamzeh F, Frank I, Eron JJ Jr, Bosch RJ, Rosenkranz SL, Cramer YS, Ussery M, Flexner C. Bakshi RP, et al. AIDS Res Hum Retroviruses. 2007 Nov;23(11):1360-5. doi: 10.1089/aid.2007.0078. AIDS Res Hum Retroviruses. 2007. PMID: 18184078 Clinical Trial.
Median intracellular dATP concentrations decreased from base-line to day 14 by 46% in the ddI + 1000 mg HU arm and by 62% in the ddI + 1500 mg HU arm. When compared to the HU monotherapy arms, these changes proved statistically significant (p = …
Median intracellular dATP concentrations decreased from base-line to day 14 by 46% in the ddI + 1000 mg HU arm and by 62% in t …
HIV hollow fiber SCID model for antiviral therapy comparison with SCID/hu model.
Taggart BR, Harrington P, Hollingshead M. Taggart BR, et al. Antiviral Res. 2004 Jul;63(1):1-6. doi: 10.1016/j.antiviral.2004.04.001. Antiviral Res. 2004. PMID: 15196814 Review.
[Antimicrob. Agents Chemother. 40 (1996) 755] described the SCID/hu (Thy/Liv) model which was developed for the evaluation of HIV pathogenic mechanisms and for the prioritization of antiviral compounds that were efficacious in vitro. ...The hollow fiber model is used as a …
[Antimicrob. Agents Chemother. 40 (1996) 755] described the SCID/hu (Thy/Liv) model which was developed for the evaluation of HIV pat …
Effects of drug-drug interactions and CYP3A4 variants on alectinib metabolism.
Liu YN, Chen J, Wang J, Li Q, Hu GX, Cai JP, Lin G, Xu RA. Liu YN, et al. Arch Toxicol. 2023 Aug;97(8):2133-2142. doi: 10.1007/s00204-023-03524-1. Epub 2023 May 20. Arch Toxicol. 2023. PMID: 37209178
In this study, the effects of 17 CYP3A4 variants and drug-drug interactions (DDI) with its mechanism on alectinib metabolism were investigated. ...
In this study, the effects of 17 CYP3A4 variants and drug-drug interactions (DDI) with its mechanism on alectinib metabolism were inv …
Prompt Tuning in Biomedical Relation Extraction.
He J, Li F, Li J, Hu X, Nian Y, Xiang Y, Wang J, Wei Q, Li Y, Xu H, Tao C. He J, et al. J Healthc Inform Res. 2024 Feb 29;8(2):206-224. doi: 10.1007/s41666-024-00162-9. eCollection 2024 Jun. J Healthc Inform Res. 2024. PMID: 38681754
The model's performance was rigorously assessed using the chemical-protein relation (CHEMPROT) dataset from BioCreative VI and the drug-drug interaction (DDI) dataset from SemEval-2013, showcasing its superior performance over conventional fine-tuned PLMs across both datas …
The model's performance was rigorously assessed using the chemical-protein relation (CHEMPROT) dataset from BioCreative VI and the drug-drug …
Quantitative prediction of CYP3A-mediated drug-drug interactions by correctly estimating fraction metabolized using human liver chimeric mice.
Miyake T, Mochizuki T, Nakagawa T, Nakamura M, Emoto C, Komiyama N, Hirabayashi M, Tsuruta S, Shimojo T, Terao K, Tachibana T. Miyake T, et al. Br J Pharmacol. 2024 Apr;181(7):1091-1106. doi: 10.1111/bph.16270. Epub 2023 Nov 28. Br J Pharmacol. 2024. PMID: 37872109
For evaluating the human DDI predictability, the six drugs were administered intravenously to Hu-PXB and SCID mice with or without ketoconazole. ...CONCLUSIONS AND IMPLICATIONS: CYP3A-mediated DDI can be predicted by correctly estimating human f(m,CYP3A,in vi …
For evaluating the human DDI predictability, the six drugs were administered intravenously to Hu-PXB and SCID mice with or wit …
Alternatives to rifampicin: A review and perspectives on the choice of strong CYP3A inducers for clinical drug-drug interaction studies.
Bolleddula J, Gopalakrishnan S, Hu P, Dong J, Venkatakrishnan K. Bolleddula J, et al. Clin Transl Sci. 2022 Sep;15(9):2075-2095. doi: 10.1111/cts.13357. Epub 2022 Jul 25. Clin Transl Sci. 2022. PMID: 35722783 Free PMC article. Review.
Reports of NA impurities in rifampicin products have created uncertainty around using rifampicin in clinical DDI studies, especially in healthy volunteers. Hence, a systematic investigation through a literature search was performed to determine possible alternative index i …
Reports of NA impurities in rifampicin products have created uncertainty around using rifampicin in clinical DDI studies, especially …
Improvement of adequate use of warfarin for the elderly using decision tree-based approaches.
Liu KE, Lo CL, Hu YH. Liu KE, et al. Methods Inf Med. 2014;53(1):47-53. doi: 10.3414/ME13-01-0027. Epub 2013 Oct 18. Methods Inf Med. 2014. PMID: 24136011 Review.
This study examines whether the effectiveness of using warfarin among elderly inpatients can be improved when machine learning techniques and data from the laboratory information system are incorporated. METHODS: Having employed 288 validated clinical cases in the DDI grou …
This study examines whether the effectiveness of using warfarin among elderly inpatients can be improved when machine learning techniques an …
Learning entity-oriented representation for biomedical relation extraction.
Hu Y, Chen Y, Qin Y, Huang R. Hu Y, et al. J Biomed Inform. 2023 Nov;147:104527. doi: 10.1016/j.jbi.2023.104527. Epub 2023 Oct 16. J Biomed Inform. 2023. PMID: 37852347
We evaluated our approach on four BioRE tasks with eight datasets, and the experiments showed that our EoR achieved state-of-the-art performance for PPI, DDI, CPI, and DPI tasks. Further analysis demonstrated the benefits of entity-oriented semantic information in handling …
We evaluated our approach on four BioRE tasks with eight datasets, and the experiments showed that our EoR achieved state-of-the-art perform …
112 results