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Did you mean diane chan (28 results)?
SIRPα-Fc fusion protein IMM01 exhibits dual anti-tumor activities by targeting CD47/SIRPα signal pathway via blocking the "don't eat me" signal and activating the "eat me" signal.
Yu J, Li S, Chen D, Liu D, Guo H, Yang C, Zhang W, Zhang L, Zhao G, Tu X, Peng L, Liu S, Bai X, Song Y, Jiang Z, Zhang R, Tian W. Yu J, et al. Among authors: chen d. J Hematol Oncol. 2022 Nov 16;15(1):167. doi: 10.1186/s13045-022-01385-2. J Hematol Oncol. 2022. PMID: 36384978 Free PMC article.
IMM47, a humanized monoclonal antibody that targets CD24, exhibits exceptional anti-tumor efficacy by blocking the CD24/Siglec-10 interaction and can be used as monotherapy or in combination with anti-PD1 antibodies for cancer immunotherapy.
Li S, Chen D, Guo H, Yang Y, Liu D, Yang C, Bai X, Zhang W, Zhang L, Zhao G, Tu X, Peng L, Liu S, Song Y, Jiang Z, Zhang R, Yu J, Tian W. Li S, et al. Among authors: chen d. Antib Ther. 2023 Sep 9;6(4):240-252. doi: 10.1093/abt/tbad020. eCollection 2023 Oct. Antib Ther. 2023. PMID: 37846296 Free PMC article.
Crystal Structure of Human CD47 in Complex with Engineered SIRPα.D1(N80A).
Yu J, Li S, Chen D, Liu D, Guo H, Yang C, Zhang W, Zhang L, Zhao G, Tu X, Peng L, Liu S, Bai X, Song Y, Jiang Z, Zhang R, Tian W. Yu J, et al. Among authors: chen d. Molecules. 2022 Aug 30;27(17):5574. doi: 10.3390/molecules27175574. Molecules. 2022. PMID: 36080360 Free PMC article.
The novel high-affinity humanized antibody IMM40H targets CD70, eliminates tumors via Fc-mediated effector functions, and interrupts CD70/CD27 signaling.
Li S, Chen D, Guo H, Liu D, Yang C, Zhang R, Wang T, Zhang F, Bai X, Yang Y, Sun N, Zhang W, Zhang L, Zhao G, Peng L, Tu X, Tian W. Li S, et al. Among authors: chen d. Front Oncol. 2023 Oct 2;13:1240061. doi: 10.3389/fonc.2023.1240061. eCollection 2023. Front Oncol. 2023. PMID: 37849799 Free PMC article.
IMM0306, a fusion protein of CD20 mAb with the CD47 binding domain of SIRPα, exerts excellent cancer killing efficacy by activating both macrophages and NK cells via blockade of CD47-SIRPα interaction and FcɣR engagement by simultaneously binding to CD47 and CD20 of B cells.
Yu J, Li S, Chen D, Liu D, Guo H, Yang C, Zhang W, Zhang L, Zhao G, Tu X, Peng L, Liu S, Bai X, Song Y, Jiang Z, Zhang R, Tian W. Yu J, et al. Among authors: chen d. Leukemia. 2023 Mar;37(3):695-698. doi: 10.1038/s41375-022-01805-9. Epub 2022 Dec 27. Leukemia. 2023. PMID: 36575242 Free PMC article. No abstract available.