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Activation of α1A -adrenoceptors desensitizes the rat aorta response to phenylephrine through a neuronal NOS pathway, a mechanism lost with ageing.
Arce C, Vicente D, Segura V, Flacco N, Montó F, Almenar L, Agüero J, Rueda J, Jiménez-Altayó F, Vila E, Noguera MA, D'Ocon P, Ivorra MD. Arce C, et al. Among authors: vicente d. Br J Pharmacol. 2017 Jul;174(13):2015-2030. doi: 10.1111/bph.13800. Epub 2017 May 10. Br J Pharmacol. 2017. PMID: 28369791 Free PMC article.
β2- and β1-Adrenoceptor Expression Exhibits a Common Regulatory Pattern With GRK2 and GRK5 in Human and Animal Models of Cardiovascular Diseases.
Montó F, Oliver E, Vicente D, Buendía F, Rueda J, Agüero J, Almenar L, Valldecabres C, Rovira E, Muedra V, Noguera MA, Ivorra MD, DʼOcon P. Montó F, et al. Among authors: vicente d. J Cardiovasc Pharmacol. 2015 Nov;66(5):478-86. doi: 10.1097/FJC.0000000000000299. J Cardiovasc Pharmacol. 2015. PMID: 26248277
Different expression of adrenoceptors and GRKs in the human myocardium depends on heart failure etiology and correlates to clinical variables.
Montó F, Oliver E, Vicente D, Rueda J, Agüero J, Almenar L, Ivorra MD, Barettino D, D'Ocon P. Montó F, et al. Among authors: vicente d. Am J Physiol Heart Circ Physiol. 2012 Aug 1;303(3):H368-76. doi: 10.1152/ajpheart.01061.2011. Epub 2012 Jun 8. Am J Physiol Heart Circ Physiol. 2012. PMID: 22685168 Free article.