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Immunosuppressive effects of circulating bile acids in human endotoxemia and septic shock: patients with liver failure are at risk.
Leonhardt J, Dorresteijn MJ, Neugebauer S, Mihaylov D, Kunze J, Rubio I, Hohberger FS, Leonhardt S, Kiehntopf M, Stahl K, Bode C, David S, Wagener FADTG, Pickkers P, Bauer M. Leonhardt J, et al. Among authors: mihaylov d. Crit Care. 2023 Sep 27;27(1):372. doi: 10.1186/s13054-023-04620-5. Crit Care. 2023. PMID: 37759239 Free PMC article.
Circulating Bile Acids in Liver Failure Activate TGR5 and Induce Monocyte Dysfunction.
Leonhardt J, Haider RS, Sponholz C, Leonhardt S, Drube J, Spengler K, Mihaylov D, Neugebauer S, Kiehntopf M, Lambert NA, Kortgen A, Bruns T, Tacke F, Hoffmann C, Bauer M, Heller R. Leonhardt J, et al. Among authors: mihaylov d. Cell Mol Gastroenterol Hepatol. 2021;12(1):25-40. doi: 10.1016/j.jcmgh.2021.01.011. Epub 2021 Feb 2. Cell Mol Gastroenterol Hepatol. 2021. PMID: 33545429 Free PMC article.
Determination of individual bile acids in acute respiratory distress syndrome reveals a specific pattern of primary and secondary bile acids and a shift to the acidic pathway as an adaptive response to the critical condition.
Harnisch LO, Mihaylov D, Bein T, Apfelbacher C, Kiehntopf M, Bauer M, Moerer O, Quintel M. Harnisch LO, et al. Among authors: mihaylov d. Clin Chem Lab Med. 2022 Mar 21;60(6):891-900. doi: 10.1515/cclm-2021-1176. Print 2022 May 25. Clin Chem Lab Med. 2022. PMID: 35313097