Inhalation delivery of dexamethasone with iSEND nanoparticles attenuates the COVID-19 cytokine storm in mice and nonhuman primates.
Meng QF, Tai W, Tian M, Zhuang X, Pan Y, Lai J, Xu Y, Xu Z, Li M, Zhao G, Yu GT, Yu G, Chen R, Jin N, Li X, Cheng G, Chen X, Rao L.
Meng QF, et al.
Sci Adv. 2023 Jun 16;9(24):eadg3277. doi: 10.1126/sciadv.adg3277. Epub 2023 Jun 14.
Sci Adv. 2023.
PMID: 37315135
Free PMC article.
Dexamethasone (DEX) is the first drug to show life-saving efficacy in patients with severe coronavirus disease 2019 (COVID-19), while DEX is associated with serious adverse effects. ...The nanoDEX, made by encapsulating DEX with the iSEND, efficiently promote …
Dexamethasone (DEX) is the first drug to show life-saving efficacy in patients with severe coronavirus disease 2019 (COVID-19), while …