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Showing results for dex in lai
Your search for Dexin Lai retrieved no results
Inhalation delivery of dexamethasone with iSEND nanoparticles attenuates the COVID-19 cytokine storm in mice and nonhuman primates.
Meng QF, Tai W, Tian M, Zhuang X, Pan Y, Lai J, Xu Y, Xu Z, Li M, Zhao G, Yu GT, Yu G, Chen R, Jin N, Li X, Cheng G, Chen X, Rao L. Meng QF, et al. Sci Adv. 2023 Jun 16;9(24):eadg3277. doi: 10.1126/sciadv.adg3277. Epub 2023 Jun 14. Sci Adv. 2023. PMID: 37315135 Free PMC article.
Dexamethasone (DEX) is the first drug to show life-saving efficacy in patients with severe coronavirus disease 2019 (COVID-19), while DEX is associated with serious adverse effects. ...The nanoDEX, made by encapsulating DEX with the iSEND, efficiently promote …
Dexamethasone (DEX) is the first drug to show life-saving efficacy in patients with severe coronavirus disease 2019 (COVID-19), while …
Early sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial.
Shehabi Y, Serpa Neto A, Howe BD, Bellomo R, Arabi YM, Bailey M, Bass FE, Kadiman SB, McArthur CJ, Reade MC, Seppelt IM, Takala J, Wise MP, Webb SA; SPICE III Study Investigators. Shehabi Y, et al. Intensive Care Med. 2021 Apr;47(4):455-466. doi: 10.1007/s00134-021-06356-8. Epub 2021 Mar 8. Intensive Care Med. 2021. PMID: 33686482 Free PMC article. Clinical Trial.
DEX was associated with lower 90-day mortality compared to usual care in patients > 65 years (odds ratio [OR], 0.83 [95% credible interval [CrI] 0.68-1.00], with 97.7% probability of reduced mortality across broad categories of illness severity. ...Two clusters were ide …
DEX was associated with lower 90-day mortality compared to usual care in patients > 65 years (odds ratio [OR], 0.83 [95% credible …
Dexmedetomidine alleviates pulmonary fibrosis through the ADORA2B-Mediated MAPK signaling pathway.
Lai X, Lin Y, Huang S, Pu L, Zeng Q, Wang Z, Huang W. Lai X, et al. Respir Res. 2023 Aug 29;24(1):214. doi: 10.1186/s12931-023-02513-3. Respir Res. 2023. PMID: 37644529 Free PMC article.
However, the underlying mechanisms of IPF remain unknown. METHODS: In our study, the role of Dex in murine pulmonary fibrosis models was determined by Dex injection intraperitoneally in vivo. ...CONCLUSIONS: Our findings suggest Dex as a potential therapeutic …
However, the underlying mechanisms of IPF remain unknown. METHODS: In our study, the role of Dex in murine pulmonary fibrosis models …
MiR-665 Participates in the Protective Effect of Dexmedetomidine in Ischemic Stroke by ROCK2/NF-κB Axis.
Liu Q, Wu J, Lai S, Li G. Liu Q, et al. Neurochem Res. 2022 Jul;47(7):2064-2075. doi: 10.1007/s11064-022-03597-x. Epub 2022 May 10. Neurochem Res. 2022. PMID: 35538293
Meanwhile, DEX decreased the expression of cytokines and LDH concentration from 184 to 126% (P < 0.001). ...In vivo, DEX decreased cerebral infarction volume and inhibited apoptosis of brain cell (P < 0.001). ...

Meanwhile, DEX decreased the expression of cytokines and LDH concentration from 184 to 126% (P < 0.001). ...In vivo, DEX de

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Early use of dexamethasone increases Nr4a1 in Kupffer cells ameliorating acute liver failure in mice in a glucocorticoid receptor-dependent manner.
Deng JW, Yang Q, Cai XP, Zhou JM, E WG, An YD, Zheng QX, Hong M, Ren YL, Guan J, Wang G, Lai SJ, Chen Z. Deng JW, et al. J Zhejiang Univ Sci B. 2020 Sept.;21(9):727-739. doi: 10.1631/jzus.B2000249. J Zhejiang Univ Sci B. 2020. PMID: 32893529 Free PMC article.
Numbers of innate immune cells, especially Kupffer cells and neutrophils, increased significantly in the Dex-treated group. In vivo experiments indicated that the therapeutic effect of Dex is exerted mainly via the glucocorticoid receptor (Gr). ...Gr-dependent Nr4a1 …
Numbers of innate immune cells, especially Kupffer cells and neutrophils, increased significantly in the Dex-treated group. In vivo e …
Dexmedetomidine enhances hypoxia-induced cancer cell progression.
Chen HY, Li GH, Tan GC, Liang H, Lai XH, Huang Q, Zhong JY. Chen HY, et al. Exp Ther Med. 2019 Dec;18(6):4820-4828. doi: 10.3892/etm.2019.8136. Epub 2019 Oct 25. Exp Ther Med. 2019. PMID: 31772647 Free PMC article.
In the present study, the effects of DEX on hypoxia-induced growth and metastasis of lung cancer cells and colorectal cancer cells was examined. ...Finally, the effects of DEX on the hypoxia-induced growth and metastatic potential of cancer cells were reversed by at …
In the present study, the effects of DEX on hypoxia-induced growth and metastasis of lung cancer cells and colorectal cancer cells wa …
Postnatal high-fat diet sex-specifically exacerbates prenatal dexamethasone-induced hypertension: Mass spectrometry-based quantitative proteomic approach.
Hsu CN, Lai WT, Lin YJ, Tain YL. Hsu CN, et al. J Nutr Biochem. 2018 Jul;57:268-275. doi: 10.1016/j.jnutbio.2018.04.006. Epub 2018 Apr 22. J Nutr Biochem. 2018. PMID: 29800813
Additionally, HF and DEX elicited renal programming in a sex-specific fashion. In males, DEX + HF increased renal parvalbumin (PVALB) and carbonic anhydrase III (CA III) protein levels. ...DEX + HF induced sex-specific alterations of protein profiles in offsp …
Additionally, HF and DEX elicited renal programming in a sex-specific fashion. In males, DEX + HF increased renal parvalbumin …
Effect of Dexmedetomidine-Assisted Intravenous Anesthesia on Gastrointestinal Motility in Colon Cancer Patients After Open Colectomy.
Ou C, Kang S, Xue R, Lai J, Zhang Y. Ou C, et al. Front Surg. 2022 Feb 25;9:842776. doi: 10.3389/fsurg.2022.842776. eCollection 2022. Front Surg. 2022. PMID: 35284494 Free PMC article.
BACKGROUND: To explore the effect of dexmedetomidine (Dex)-assisted intravenous anesthesia on gastrointestinal motility in patients with colon cancer (CC) after open colectomy. ...The patients in the control group received a routine combination of intravenous and inhalatio …
BACKGROUND: To explore the effect of dexmedetomidine (Dex)-assisted intravenous anesthesia on gastrointestinal motility in patients w …
Regulation of Leptin Methylation Not via Apoptosis by Melatonin in the Rescue of Chronic Programming Liver Steatosis.
Tsai CC, Lin YJ, Yu HR, Sheen JM, Lin IC, Lai YJ, Tain YL, Huang LT, Tiao MM. Tsai CC, et al. Int J Mol Sci. 2018 Nov 12;19(11):3565. doi: 10.3390/ijms19113565. Int J Mol Sci. 2018. PMID: 30424542 Free PMC article.

Expression of leptin and its receptor decreased in the DEX (p < 0.05) and increased in the DEX+MEL group (p < 0.05), as revealed by RT-PCR and Western blotting. ...Liver DNA methyltransferase activity and leptin methylation increased in the DEX group (p

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Expression of leptin and its receptor decreased in the DEX (p < 0.05) and increased in the DEX+MEL group (p < 0.05), as

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41 results