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Showing results for dex in jiang
Search for Dexin Jiang instead (2 results)
Dexmedetomidine attenuates myocardial ischemia/reperfusion-induced ferroptosis via AMPK/GSK-3β/Nrf2 axis.
Wang Z, Yao M, Jiang L, Wang L, Yang Y, Wang Q, Qian X, Zhao Y, Qian J. Wang Z, et al. Biomed Pharmacother. 2022 Oct;154:113572. doi: 10.1016/j.biopha.2022.113572. Epub 2022 Aug 18. Biomed Pharmacother. 2022. PMID: 35988428 Free article.
Dex significantly increased the expression levels of Nrf2, SLC7A11, and GPX4. However, inhibition of Nrf2 by ML385 blunted the protective effect of Dex in HR-treated H9c2 cells. Inhibition of AMPK with a specific inhibitor or siRNA decreased the expression levels of …
Dex significantly increased the expression levels of Nrf2, SLC7A11, and GPX4. However, inhibition of Nrf2 by ML385 blunted the protec …
The Role and Mechanism of SIRT1 in Resveratrol-regulated Osteoblast Autophagy in Osteoporosis Rats.
Yang X, Jiang T, Wang Y, Guo L. Yang X, et al. Sci Rep. 2019 Dec 5;9(1):18424. doi: 10.1038/s41598-019-44766-3. Sci Rep. 2019. PMID: 31804494 Free PMC article.
On the other hand, resveratrol treatment increased the SIRT1 activity, LC3 and Beclin-1 mRNA expression in the dexamethasone (DEX)-treated osteoblasts. More mitophagosomes were observed in the DEX-treated osteoblasts with resveratrol. Meanwhile, the TOM20, Hsp60, p- …
On the other hand, resveratrol treatment increased the SIRT1 activity, LC3 and Beclin-1 mRNA expression in the dexamethasone (DEX)-tr …
Targeting BCL-2 with venetoclax and dexamethasone in patients with relapsed/refractory t(11;14) multiple myeloma.
Kaufman JL, Gasparetto C, Schjesvold FH, Moreau P, Touzeau C, Facon T, Boise LH, Jiang Y, Yang X, Dunbar F, Vishwamitra D, Unger S, Macartney T, Pesko J, Yu Y, Salem AH, Ross JA, Hong WJ, Maciag PC, Pauff JM, Kumar S. Kaufman JL, et al. Am J Hematol. 2021 Apr 1;96(4):418-427. doi: 10.1002/ajh.26083. Epub 2021 Jan 19. Am J Hematol. 2021. PMID: 33368455 Free PMC article. Clinical Trial.
Patients in both phases received VenDex (oral Ven 800 mg/day + oral Dex 40 mg [20 mg for patients 75 years] on days 1, 8, and 15, per 21-day cycle). ...
Patients in both phases received VenDex (oral Ven 800 mg/day + oral Dex 40 mg [20 mg for patients 75 years] on days 1, 8, and 15, per …
Effects of Puerarin-Loaded Tetrahedral Framework Nucleic Acids on Osteonecrosis of the Femoral Head.
Zhao Y, Li S, Feng M, Zhang M, Liu Z, Yao Y, Zhang T, Jiang Y, Lin Y, Cai X. Zhao Y, et al. Small. 2023 Oct;19(41):e2302326. doi: 10.1002/smll.202302326. Epub 2023 Jun 14. Small. 2023. PMID: 37317020
In this study, tFNAs as Pue carriers is used and synthesized a tFNA/Pue complex (TPC) that exhibited better stability, biocompatibility, and tissue utilization than free Pue. A dexamethasone (DEX)-treated BMSC model in vitro and a methylprednisolone (MPS)-induced ONFH mode …
In this study, tFNAs as Pue carriers is used and synthesized a tFNA/Pue complex (TPC) that exhibited better stability, biocompatibility, and …
Tetrahedral Framework Nucleic Acids Inhibit Muscular Mitochondria-Mediated Apoptosis and Ameliorate Muscle Atrophy in Sarcopenia.
Yu X, Wang Y, Ran L, Jiang Y, Chen M, Du H, Zhang Y, Wu D, Xiang X, Zhang J, Jiang N, He H, Song Y, Xiang Z, He C, Zhou Z, Zeng J, Xiang Y, Huang SS, Lin Y. Yu X, et al. Nano Lett. 2023 Sep 27;23(18):8816-8826. doi: 10.1021/acs.nanolett.3c01502. Epub 2023 Jul 17. Nano Lett. 2023. PMID: 37459451
Results from muscular biophysiological characteristics demonstrated significant improvement in muscle function and endurance in the aged mouse model, and histologic examinations also showed beneficial morphological changes in muscle fibers. In vitro, DEX-induced sarcopenic …
Results from muscular biophysiological characteristics demonstrated significant improvement in muscle function and endurance in the aged mou …
Regulating macrophage-MSC interaction to optimize BMP-2-induced osteogenesis in the local microenvironment.
Jiang F, Qi X, Wu X, Lin S, Shi J, Zhang W, Jiang X. Jiang F, et al. Bioact Mater. 2023 Feb 11;25:307-318. doi: 10.1016/j.bioactmat.2023.02.001. eCollection 2023 Jul. Bioact Mater. 2023. PMID: 36844362 Free PMC article.
As the dose of BMP-2 increased, the IL-1beta expression and M1 infiltration in local microenvironment were inhibited by IL-1Ra from MSCs under osteogenic differentiation induced by BMP-2, and new bone tissues formed, even excessively. Anti-inflammatory drugs (Dexamethasone, De …
As the dose of BMP-2 increased, the IL-1beta expression and M1 infiltration in local microenvironment were inhibited by IL-1Ra from MSCs und …
Dexamethasone induces ferroptosis via P53/SLC7A11/GPX4 pathway in glucocorticoid-induced osteonecrosis of the femoral head.
Sun F, Zhou JL, Liu ZL, Jiang ZW, Peng H. Sun F, et al. Biochem Biophys Res Commun. 2022 Apr 30;602:149-155. doi: 10.1016/j.bbrc.2022.02.112. Epub 2022 Mar 1. Biochem Biophys Res Commun. 2022. PMID: 35276555
The results in vitro experiments show that Dex can induce MC3T3-E1 cells ferroptosis by down-regulating SLC7A11. ...Thus, this study demonstrated that Dex induces MC3T3-E1cells ferroptosis via p53/SLC7A11/GPX4 pathway. ...
The results in vitro experiments show that Dex can induce MC3T3-E1 cells ferroptosis by down-regulating SLC7A11. ...Thus, this study …
Dendrobium offificinale polysaccharides prevents glucocorticoids-induced osteoporosis by destabilizing KEAP1-NRF2 interaction.
Wang Y, Jiang Z, Deng L, Zhang G, Xu X, Alonge E, Zhang H, Guo C. Wang Y, et al. Int J Biol Macromol. 2023 Dec 31;253(Pt 1):126600. doi: 10.1016/j.ijbiomac.2023.126600. Epub 2023 Aug 29. Int J Biol Macromol. 2023. PMID: 37652317
Importantly, we found that DOP treatment significantly inhibited DEX-induced osteoporosis in two in vivo models, zebrafish and mice, while boosting osteogenic differentiation of hBMSCs exposed to DEX. ...Taken together, these results illuminate that DOP stimulates o …
Importantly, we found that DOP treatment significantly inhibited DEX-induced osteoporosis in two in vivo models, zebrafish and mice, …
Dexmedetomidine postconditioning attenuates myocardial ischemia/reperfusion injury by activating the Nrf2/Sirt3/SOD2 signaling pathway in the rats.
Hu B, Tian T, Li XT, Hao PP, Liu WC, Chen YG, Jiang TY, Chen PS, Cheng Y, Xue FS. Hu B, et al. Redox Rep. 2023 Dec;28(1):2158526. doi: 10.1080/13510002.2022.2158526. Redox Rep. 2023. PMID: 36738240 Free PMC article.
METHODS: One-hundred forty-seven male Sprague-Dawley rats were randomly divided into five groups receiving the different treatments: Sham, ischemia/reperfusion (I/R), Dex, Brusatol, Dex + Brusatol. By the in vivo rat model of myocardial IRI, cardioprotective effects …
METHODS: One-hundred forty-seven male Sprague-Dawley rats were randomly divided into five groups receiving the different treatments: Sham, i …
Precisely Regulating M2 Subtype Macrophages for Renal Fibrosis Resolution.
Luo L, Wang S, Hu Y, Wang L, Jiang X, Zhang J, Liu X, Guo X, Luo Z, Zhu C, Xie M, Li Y, You J, Yang F. Luo L, et al. ACS Nano. 2023 Nov 28;17(22):22508-22526. doi: 10.1021/acsnano.3c05998. Epub 2023 Nov 10. ACS Nano. 2023. PMID: 37948096
Based on these findings, we employed targeted nanotechnology to codeliver endoplasmic reticulum stress (ERS) inhibitor (Ceapin 7, Cea or C) and conventional glucocorticoids (Dexamethasone, Dex or D), precisely modulating the ATF6/TGF-beta/Smad3 signaling axis within macrop …
Based on these findings, we employed targeted nanotechnology to codeliver endoplasmic reticulum stress (ERS) inhibitor (Ceapin 7, Cea or C) …
279 results