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Showing results for dex in gao
Search for Dexin Gao instead (3 results)
ROS-responsive polymer nanoparticles with enhanced loading of dexamethasone effectively modulate the lung injury microenvironment.
Muhammad W, Zhu J, Zhai Z, Xie J, Zhou J, Feng X, Feng B, Pan Q, Li S, Venkatesan R, Li P, Cao H, Gao C. Muhammad W, et al. Acta Biomater. 2022 Aug;148:258-270. doi: 10.1016/j.actbio.2022.06.024. Epub 2022 Jun 18. Acta Biomater. 2022. PMID: 35724918 Free PMC article.
DEX was released faster from the PFTU@DEX NPs in a ROS environment, which could scavenge excessive ROS efficiently both in vitro and in vivo. The PFTU NPs and PFTU@DEX NPs showed no hemolysis and cytotoxicity. Free DEX, PFTU NPs and PFTU@DEX NPs …
DEX was released faster from the PFTU@DEX NPs in a ROS environment, which could scavenge excessive ROS efficiently both in vit …
Universal immunotherapeutic strategy for hepatocellular carcinoma with exosome vaccines that engage adaptive and innate immune responses.
Zuo B, Zhang Y, Zhao K, Wu L, Qi H, Yang R, Gao X, Geng M, Wu Y, Jing R, Zhou Q, Seow Y, Yin H. Zuo B, et al. J Hematol Oncol. 2022 Apr 29;15(1):46. doi: 10.1186/s13045-022-01266-8. J Hematol Oncol. 2022. PMID: 35488312 Free PMC article.
METHODS: Here, we demonstrate a general strategy for biological nanovaccines that trigger tailored tumor-specific immune responses for hepatocellular carcinoma (HCC). Dendritic cell (DC)-derived exosomes (DEX) are painted with a HCC-targeting peptide (P47-P), an alpha-feto …
METHODS: Here, we demonstrate a general strategy for biological nanovaccines that trigger tailored tumor-specific immune responses for hepat …
Reactive oxygen species-responsive nanocarrier ameliorates murine colitis by intervening colonic innate and adaptive immune responses.
Yan X, Meng L, Zhang X, Deng Z, Gao B, Zhang Y, Yang M, Ma Y, Zhang Y, Tu K, Zhang M, Xu Q. Yan X, et al. Mol Ther. 2023 May 3;31(5):1383-1401. doi: 10.1016/j.ymthe.2023.02.017. Epub 2023 Feb 28. Mol Ther. 2023. PMID: 36855303
More importantly, the combination of the PSB and dexamethasone (DEX) enhanced the therapeutic efficacy of colitis. This ROS-responsive and ROS-scavenging nanocarrier represents an alternative therapeutic approach to UC. ...
More importantly, the combination of the PSB and dexamethasone (DEX) enhanced the therapeutic efficacy of colitis. This ROS-responsiv …
Dexmedetomidine Regulates Autophagy via the AMPK/mTOR Pathway to Improve SH-SY5Y-APP Cell Damage Induced by High Glucose.
Chen P, Chen X, Zhang H, Chen J, Lin M, Qian H, Gao F, Chen Y, Gong C, Zheng X, Zheng T. Chen P, et al. Neuromolecular Med. 2023 Sep;25(3):415-425. doi: 10.1007/s12017-023-08745-2. Epub 2023 Apr 5. Neuromolecular Med. 2023. PMID: 37017880
Furthermore, RAPA had a protective effect similar to that of DEX, but 3-MA eliminated the protective effect of DEX by promoting mTOR activation. Moreover, the AMPK/mTOR pathway was involved in DEX-mediated autophagy. Compound C significantly suppressed autoph …
Furthermore, RAPA had a protective effect similar to that of DEX, but 3-MA eliminated the protective effect of DEX by promotin …
Intraoperative dexmedetomidine on postoperative pain in gastrointestinal surgery: an observational study.
Lv X, Zhang H, Gao J, Hou A, Ma Y, Zhou Z, Mi W, Zhang H, Liu Y. Lv X, et al. Int J Surg. 2023 Apr 1;109(4):887-895. doi: 10.1097/JS9.0000000000000360. Int J Surg. 2023. PMID: 36999795 Free PMC article.
BACKGROUND: Dexmedetomidine (DEX) is widely used for adjuvant sedation and analgesia in gastrointestinal surgeries. ...MATERIALS AND METHODS: In this multicentre cohort study, patients undergoing gastrointestinal surgeries were prospectively enrolled in the China Acute Pos …
BACKGROUND: Dexmedetomidine (DEX) is widely used for adjuvant sedation and analgesia in gastrointestinal surgeries. ...MATERIALS AND …
Expression of NEAT1 can be used as a predictor for Dex resistance in multiple myeloma patients.
Ren Y, Liu Y, He W, Zhao W, Pan J, Gao H, Li Y, Zhang Y, Wang W. Ren Y, et al. BMC Cancer. 2023 Jul 5;23(1):630. doi: 10.1186/s12885-023-11084-x. BMC Cancer. 2023. PMID: 37407915 Free PMC article.
Nevertheless, their use is severely hampered by the risk of developing side effects and the occurrence of Dex resistance. LncRNA NEAT1 plays a oncogenic role and participates in drug resistance in many solid tumors. ...NEAT1 invovled in Dex resistance, which provide …
Nevertheless, their use is severely hampered by the risk of developing side effects and the occurrence of Dex resistance. LncRNA NEAT …
Mesenchymal stem cells, as glioma exosomal immunosuppressive signal multipliers, enhance MDSCs immunosuppressive activity through the miR-21/SP1/DNMT1 positive feedback loop.
Qiu W, Guo Q, Guo X, Wang C, Li B, Qi Y, Wang S, Zhao R, Han X, Du H, Zhao S, Pan Z, Fan Y, Wang Q, Gao Z, Li G, Xue H. Qiu W, et al. J Nanobiotechnology. 2023 Jul 22;21(1):233. doi: 10.1186/s12951-023-01997-x. J Nanobiotechnology. 2023. PMID: 37481646 Free PMC article.
Further study showed that the miR-21/SP1/DNMT1 positive feedback loop in MSCs triggered by glioma exosomal CD44 upregulated MSC exosomal miR-21 expression, amplifying the glioma exosomal immunosuppressive signal. Modified dendritic cell-derived exosomes (Dex) carrying miR- …
Further study showed that the miR-21/SP1/DNMT1 positive feedback loop in MSCs triggered by glioma exosomal CD44 upregulated MSC exosomal miR …
Prenatal dexamethasone exposure impaired vascular reactivity in adult male offspring cerebral arteries.
Lei J, Zhao M, Deng F, Xu T, Ji B, Wang X, Zhang M, Sun M, Gao Q. Lei J, et al. J Mol Cell Cardiol. 2023 Aug;181:46-56. doi: 10.1016/j.yjmcc.2023.05.008. Epub 2023 Jun 2. J Mol Cell Cardiol. 2023. PMID: 37271369
Our results showed that prenatal DEX exposure increased the sensitivity of offspring MCA to Angiotensin II, which was resulted from the increased Cav1.2 (L-type Ca(2+) channels subunit alpha1 C). Mechanistically, prenatal DEX exposure resulted in a transcriptionally …
Our results showed that prenatal DEX exposure increased the sensitivity of offspring MCA to Angiotensin II, which was resulted from t …
In situ-activated photothermal nanoplatform for on-demand NO gas delivery and enhanced colorectal cancer treatment.
Xin Y, Yu Y, Su M, Li X, Elsabahy M, Gao H. Xin Y, et al. J Control Release. 2023 Jul;359:69-84. doi: 10.1016/j.jconrel.2023.05.034. Epub 2023 Jun 1. J Control Release. 2023. PMID: 37245723
Herein, we engineer an in situ-activated anti-tumor and antibacterial nanoplatform (Cu(2)O/BNN6@MSN-Dex) to allow photoacoustic (PA) imaging-guided photothermal and NO gas combinatorial therapy for enhanced Fn-associated CRC treatment. ...Furthermore, Cu(2)O/BNN6@MSN-De …
Herein, we engineer an in situ-activated anti-tumor and antibacterial nanoplatform (Cu(2)O/BNN6@MSN-Dex) to allow photoacoustic (PA) …
250 results