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Resistance profiling of Aspergillus fumigatus to olorofim indicates absence of intrinsic resistance and unveils the molecular mechanisms of acquired olorofim resistance.
Buil JB, Oliver JD, Law D, Baltussen T, Zoll J, Hokken MWJ, Tehupeiory-Kooreman M, Melchers WJG, Birch M, Verweij PE. Buil JB, et al. Among authors: law d. Emerg Microbes Infect. 2022 Dec;11(1):703-714. doi: 10.1080/22221751.2022.2034485. Emerg Microbes Infect. 2022. PMID: 35109772 Free PMC article.
F901318 represents a novel class of antifungal drug that inhibits dihydroorotate dehydrogenase.
Oliver JD, Sibley GEM, Beckmann N, Dobb KS, Slater MJ, McEntee L, du Pré S, Livermore J, Bromley MJ, Wiederhold NP, Hope WW, Kennedy AJ, Law D, Birch M. Oliver JD, et al. Among authors: law d. Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):12809-12814. doi: 10.1073/pnas.1608304113. Epub 2016 Oct 25. Proc Natl Acad Sci U S A. 2016. PMID: 27791100 Free PMC article.
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