Structural characterization and in silico toxicity prediction of degradation impurities of roxadustat.
Mahajan R, Kumar S, Parupalli R, Khemchandani R, Kanchupalli V, Nanduri S, Samanthula G, Asthana A.
Mahajan R, et al.
J Pharm Biomed Anal. 2023 Sep 20;234:115517. doi: 10.1016/j.jpba.2023.115517. Epub 2023 Jun 8.
J Pharm Biomed Anal. 2023.
PMID: 37320975
DP-4 is chemically, (1a-methyl-6-oxo-3-phenoxy-1,1a,6,6a-tetrahydroindeno [1,2-b] aziridine-6a-carbonyl) glycine. In silico toxicity study was conducted using Dereck software to gain the best knowledge of the drug and its degradation products towards carcinogenicity, mutag …
DP-4 is chemically, (1a-methyl-6-oxo-3-phenoxy-1,1a,6,6a-tetrahydroindeno [1,2-b] aziridine-6a-carbonyl) glycine. In silico toxicity study w …