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Characterization of the ATP4 ion pump in Toxoplasma gondii.
Lehane AM, Dennis ASM, Bray KO, Li D, Rajendran E, McCoy JM, McArthur HM, Winterberg M, Rahimi F, Tonkin CJ, Kirk K, van Dooren GG. Lehane AM, et al. J Biol Chem. 2019 Apr 5;294(14):5720-5734. doi: 10.1074/jbc.RA118.006706. Epub 2019 Feb 5. J Biol Chem. 2019. PMID: 30723156 Free PMC article.
PfATP4 was originally annotated as a Ca(2+) transporter, but recent evidence suggests that it is a Na(+) efflux pump, extruding Na(+) in exchange for H(+) Here we demonstrate that ATP4 proteins belong to a clade of P-type ATPases that are restricted to apicomplexans and th …
PfATP4 was originally annotated as a Ca(2+) transporter, but recent evidence suggests that it is a Na(+) efflux pump, extruding Na(+) in exc …
Safety and immunogenicity of a trivalent virus-like particle vaccine against western, eastern, and Venezuelan equine encephalitis viruses: a phase 1, open-label, dose-escalation, randomised clinical trial.
Coates EE, Edupuganti S, Chen GL, Happe M, Strom L, Widge A, Florez MB, Cox JH, Gordon I, Plummer S, Ola A, Yamshchikov G, Andrews C, Curate-Ingram S, Morgan P, Nagar S, Collins MH, Bray A, Nguyen T, Stein J, Case CL, Kaltovich F, Wycuff D, Liang CJ, Carlton K, Vazquez S, Mascola JR, Ledgerwood JE; VRC 313 Study Team. Coates EE, et al. Lancet Infect Dis. 2022 Aug;22(8):1210-1220. doi: 10.1016/S1473-3099(22)00052-4. Epub 2022 May 11. Lancet Infect Dis. 2022. PMID: 35568049 Free PMC article. Clinical Trial.
Dose-dependent differences in the frequency of pain and tenderness were found between the 6 mug, 30 mug, and 60 mug groups (p=0.0217). No significant differences were observed between dosing groups for any other reactogenicity symptom. ...
Dose-dependent differences in the frequency of pain and tenderness were found between the 6 mug, 30 mug, and 60 mug groups (p=0.0217) …
Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial.
FOCUS Trial Collaboration. FOCUS Trial Collaboration. Lancet. 2019 Jan 19;393(10168):265-274. doi: 10.1016/S0140-6736(18)32823-X. Epub 2018 Dec 5. Lancet. 2019. PMID: 30528472 Free PMC article. Clinical Trial.
The distribution across mRS categories at 6 months was similar in the fluoxetine and placebo groups (common odds ratio adjusted for minimisation variables 0.951 [95% CI 0.839-1.079]; p=0.439). Patients allocated fluoxetine were less likely than those allocated placebo to d …
The distribution across mRS categories at 6 months was similar in the fluoxetine and placebo groups (common odds ratio adjusted for minimisa …