Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease. The friend leukemia insertion site 1 (Fli-1) belongs to the Ets family of transcription factors. Recent findings suggested that expression of Fli-1 was abnormal in SLE patients and lupus mice. In addition, functional analysis indicated that Fli-1 plays a key role in the development of this complex autoimmune disorder. Here, we review the updated evidence indicating the roles of Fli-1 in autoimmune lupus. Hopefully, the information obtained may result in a better understanding of the pathogenesis of the systemic autoimmune disease.
Keywords:
autoimmune; fli-1; lupus.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Autoantibodies / immunology*
-
Cell Differentiation / genetics
-
Cytokines / biosynthesis
-
Cytokines / immunology
-
Disease Models, Animal
-
Humans
-
Inflammation / immunology
-
Lupus Erythematosus, Systemic / genetics*
-
Lupus Erythematosus, Systemic / immunology*
-
Lupus Erythematosus, Systemic / pathology
-
Lymphocytes / cytology
-
Lymphocytes / immunology*
-
Mice
-
Microfilament Proteins / genetics*
-
Receptors, Cytoplasmic and Nuclear / genetics*
-
Trans-Activators
Substances
-
Autoantibodies
-
Cytokines
-
FLII protein, human
-
Microfilament Proteins
-
Receptors, Cytoplasmic and Nuclear
-
Trans-Activators