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Pharmacokinetics and urine metabolite identification of dehydroevodiamine in the rat.
Lin LC, Li SH, Wu YT, Kuo KL, Tsai TH. Lin LC, et al. J Agric Food Chem. 2012 Feb 22;60(7):1595-604. doi: 10.1021/jf204365m. Epub 2012 Feb 9. J Agric Food Chem. 2012. PMID: 22283510
The protein binding of DeHE in rat plasma was 65.6 6.5%. Six metabolites, including five DeHE-O-glucuronides and one DeHE-sulfate, were identified after oral administration. The structures of two glucuronide conjugates, DeHE-10-O-glucuronide (M3) and …
The protein binding of DeHE in rat plasma was 65.6 6.5%. Six metabolites, including five DeHE-O-glucuronides and one DeHE …
Thermoregulatory effects of alkaloids isolated from Wu-chu-yu in afebrile and febrile rats.
Tsai TH, Lee TF, Chen CF, Wang LC. Tsai TH, et al. Pharmacol Biochem Behav. 1995 Feb;50(2):293-8. doi: 10.1016/0091-3057(94)00317-c. Pharmacol Biochem Behav. 1995. PMID: 7740070
Dehydroevodiamine (DeHE) and evodiamine (EVO), alkaloids isolated from a Chinese medicinal herb, Wu-chu-yu, exhibit calcium antagonistic activity. Intraperitoneal injections of DeHE (5-20 mg/kg) and EVO (2.5-10 mg/kg) caused a dose-related hypothermia in afebrile ra …
Dehydroevodiamine (DeHE) and evodiamine (EVO), alkaloids isolated from a Chinese medicinal herb, Wu-chu-yu, exhibit calcium antagonis …
Lack of calcium-antagonizing activity of dehydroevodiamine on the chronotropic and inotropic activities of mouse isolated atria.
Wong KK. Wong KK. Planta Med. 1996 Jun;62(3):246-9. doi: 10.1055/s-2006-957869. Planta Med. 1996. PMID: 8693038
Dehydroevodiamine (DeHE) was reported to induce bradycardia and to have calcium-antagonizing activity besides other actions. ...The data showed that DeHE induced bradycardia but did not decrease the contraction amplitude of the right atrium. ...
Dehydroevodiamine (DeHE) was reported to induce bradycardia and to have calcium-antagonizing activity besides other actions. ...The d …