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Page 1
Showing results for deep krishnan
Search for Deepu Krishnan instead (2 results)
Teclistamab in Relapsed or Refractory Multiple Myeloma.
Moreau P, Garfall AL, van de Donk NWCJ, Nahi H, San-Miguel JF, Oriol A, Nooka AK, Martin T, Rosinol L, Chari A, Karlin L, Benboubker L, Mateos MV, Bahlis N, Popat R, Besemer B, Martínez-López J, Sidana S, Delforge M, Pei L, Trancucci D, Verona R, Girgis S, Lin SXW, Olyslager Y, Jaffe M, Uhlar C, Stephenson T, Van Rampelbergh R, Banerjee A, Goldberg JD, Kobos R, Krishnan A, Usmani SZ. Moreau P, et al. N Engl J Med. 2022 Aug 11;387(6):495-505. doi: 10.1056/NEJMoa2203478. Epub 2022 Jun 5. N Engl J Med. 2022. PMID: 35661166 Free PMC article. Clinical Trial.
Neurotoxic events occurred in 24 patients (14.5%), including immune effector cell-associated neurotoxicity syndrome in 5 patients (3.0%; all grade 1 or 2). CONCLUSIONS: Teclistamab resulted in a high rate of deep and durable response in patients with triple-class-exposed r …
Neurotoxic events occurred in 24 patients (14.5%), including immune effector cell-associated neurotoxicity syndrome in 5 patients (3.0%; all …
Discovery of a structural class of antibiotics with explainable deep learning.
Wong F, Zheng EJ, Valeri JA, Donghia NM, Anahtar MN, Omori S, Li A, Cubillos-Ruiz A, Krishnan A, Jin W, Manson AL, Friedrichs J, Helbig R, Hajian B, Fiejtek DK, Wagner FF, Soutter HH, Earl AM, Stokes JM, Renner LD, Collins JJ. Wong F, et al. Nature. 2024 Feb;626(7997):177-185. doi: 10.1038/s41586-023-06887-8. Epub 2023 Dec 20. Nature. 2024. PMID: 38123686
The discovery of novel structural classes of antibiotics is urgently needed to address the ongoing antibiotic resistance crisis(1-9). Deep learning approaches have aided in exploring chemical spaces(1,10-15); these typically use black box models and do not provide chemical …
The discovery of novel structural classes of antibiotics is urgently needed to address the ongoing antibiotic resistance crisis(1-9). Dee
Deep brain stimulation for movement disorders.
Krishnan S, Pisharady KK, Divya KP, Shetty K, Kishore A. Krishnan S, et al. Neurol India. 2018 Mar-Apr;66(Supplement):S90-S101. doi: 10.4103/0028-3886.226438. Neurol India. 2018. PMID: 29503331 Free article. Review.
Deep Brain Stimulation (DBS) was introduced into clinical practice nearly four decades ago and is currently the standard of care for patients with Parkinson's disease experiencing motor complications. ...
Deep Brain Stimulation (DBS) was introduced into clinical practice nearly four decades ago and is currently the standard of care for
Cervical Radiculopathy.
Magnus W, Viswanath O, Viswanathan VK, Mesfin FB. Magnus W, et al. 2024 Jan 31. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2024 Jan 31. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 28722858 Free Books & Documents.
Cervical radiculopathy, on the other hand, is a condition where the nerve root of a spinal nerve is compressed or impaired, causing the pain and symptoms to spread beyond the neck and radiate to other areas of the body, such as the arms, neck, chest, upper back, and shoulders. Du …
Cervical radiculopathy, on the other hand, is a condition where the nerve root of a spinal nerve is compressed or impaired, causing the pain …
De Novo Structure-Based Drug Design Using Deep Learning.
Krishnan SR, Bung N, Vangala SR, Srinivasan R, Bulusu G, Roy A. Krishnan SR, et al. J Chem Inf Model. 2022 Nov 14;62(21):5100-5109. doi: 10.1021/acs.jcim.1c01319. Epub 2021 Nov 18. J Chem Inf Model. 2022. PMID: 34792338 Review.
In recent years, deep learning-based methods have emerged as promising tools for de novo drug design. ...Although there have been attempts to develop alternative ways to design target-specific ligand data sets, availability of such data sets remains a challenge while desig …
In recent years, deep learning-based methods have emerged as promising tools for de novo drug design. ...Although there have been att …
Daratumumab plus pomalidomide and dexamethasone in relapsed and/or refractory multiple myeloma.
Chari A, Suvannasankha A, Fay JW, Arnulf B, Kaufman JL, Ifthikharuddin JJ, Weiss BM, Krishnan A, Lentzsch S, Comenzo R, Wang J, Nottage K, Chiu C, Khokhar NZ, Ahmadi T, Lonial S. Chari A, et al. Blood. 2017 Aug 24;130(8):974-981. doi: 10.1182/blood-2017-05-785246. Epub 2017 Jun 21. Blood. 2017. PMID: 28637662 Free PMC article. Clinical Trial.
Aside from increased neutropenia, the safety profile of daratumumab plus pom-dex was consistent with that of the individual therapies. Deep, durable responses were observed in heavily treated patients. ...
Aside from increased neutropenia, the safety profile of daratumumab plus pom-dex was consistent with that of the individual therapies. De
Chronic Venous Insufficiency.
Gujja K, Wiley J, Krishnan P. Gujja K, et al. Interv Cardiol Clin. 2014 Oct;3(4):593-605. doi: 10.1016/j.iccl.2014.07.001. Epub 2014 Oct 2. Interv Cardiol Clin. 2014. PMID: 28582082 Review.
Replay in Deep Learning: Current Approaches and Missing Biological Elements.
Hayes TL, Krishnan GP, Bazhenov M, Siegelmann HT, Sejnowski TJ, Kanan C. Hayes TL, et al. Neural Comput. 2021 Oct 12;33(11):2908-2950. doi: 10.1162/neco_a_01433. Neural Comput. 2021. PMID: 34474476 Free PMC article.
Replay algorithms have been successfully used in a wide range of deep learning methods within supervised, unsupervised, and reinforcement learning paradigms. ...We identify multiple aspects of biological replay that are missing in deep learning systems and hypothesi …
Replay algorithms have been successfully used in a wide range of deep learning methods within supervised, unsupervised, and reinforce …
277 results