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CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality.
Tien JC, Chang Y, Zhang Y, Chou J, Cheng Y, Wang X, Yang J, Mannan R, Shah P, Wang XM, Todd AJ, Eyunni S, Cheng C, Rebernick RJ, Xiao L, Bao Y, Neiswender J, Brough R, Pettitt SJ, Cao X, Miner SJ, Zhou L, Wu YM, Labanca E, Wang Y, Parolia A, Cieslik M, Robinson DR, Wang Z, Feng FY, Lord CJ, Ding K, Chinnaiyan AM. Tien JC, et al. bioRxiv [Preprint]. 2024 Mar 21:2024.03.20.585990. doi: 10.1101/2024.03.20.585990. bioRxiv. 2024. PMID: 38562774 Free PMC article. Preprint.
Here, we demonstrate that tissue-specific Cdk12 ablation is sufficient to induce preneoplastic lesions and robust T cell infiltration in the mouse prostate. Allograft-based CRISPR screening demonstrated that Cdk12 loss is positively associated with Trp53 inactivation but n …
Here, we demonstrate that tissue-specific Cdk12 ablation is sufficient to induce preneoplastic lesions and robust T cell infiltration …
Impact of age on long-term anticoagulation and how gender and monitoring setting affect it: implications for decision making and patient management.
Abohelaika S, Wynne H, Avery P, Robinson B, Kesteven P, Kamali F. Abohelaika S, et al. Br J Clin Pharmacol. 2016 Oct;82(4):1076-83. doi: 10.1111/bcp.13046. Epub 2016 Jul 24. Br J Clin Pharmacol. 2016. PMID: 27314636 Free PMC article.
METHODS: In atrial fibrillation (AF) patients of a unified anticoagulant service monitoring patients in general practice or hospital-based clinics and housebound patients at home, international normalized ratio (INR) and warfarin dose data between 2000 and 2013 were extracted via …
METHODS: In atrial fibrillation (AF) patients of a unified anticoagulant service monitoring patients in general practice or hospital-based c …
Individual foraging strategies reveal niche overlap between endangered galapagos pinnipeds.
Villegas-Amtmann S, Jeglinski JW, Costa DP, Robinson PW, Trillmich F. Villegas-Amtmann S, et al. PLoS One. 2013 Aug 15;8(8):e70748. doi: 10.1371/journal.pone.0070748. eCollection 2013. PLoS One. 2013. PMID: 23967096 Free PMC article.
Most sea lion dives also occurred at night (63%), between 0-40 m, within fur seals' diving depth range. 34% of sea lions night dives occurred at 19-22 h, when fur seals dived the most, but most of them occurred at dawn and dusk, when fur seals exhibited the least amount of …
Most sea lion dives also occurred at night (63%), between 0-40 m, within fur seals' diving depth range. 34% of sea lions night dives occurre …
Samplers for evaluation and quantification of ultra-low volume space sprays.
Farooq M, Hoffmann WC, Walker TW, Smith VL, Robinson CA, Dunford JC, Sutherland IW. Farooq M, et al. J Am Mosq Control Assoc. 2009 Dec;25(4):521-4. doi: 10.2987/09-0009R.1. J Am Mosq Control Assoc. 2009. PMID: 20099603 Free article.
Water and BVA13 oil with fluorescent dyes as tracers were sprayed with the use of a truck-mounted ULV sprayer at dusk and dawn. Results suggest that the horizontal and rotating cotton ribbons are best for quantification of airborne spray and filter paper is best for ground …
Water and BVA13 oil with fluorescent dyes as tracers were sprayed with the use of a truck-mounted ULV sprayer at dusk and dawn. Resul …