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Page 1
Tacrolimus use in lupus nephritis: A systematic review and meta-analysis.
Hannah J, Casian A, D'Cruz D. Hannah J, et al. Autoimmun Rev. 2016 Jan;15(1):93-101. doi: 10.1016/j.autrev.2015.09.006. Epub 2015 Sep 30. Autoimmun Rev. 2016. PMID: 26427983 Review.
The meta-analysis showed that overall tacrolimus is more effective at inducing complete renal remission than IVCYC (p=0.004), but there is no significant difference compared to MMF (p=0.87). ...Mortality was lower in the tacrolimus groups, but this was not statistic …
The meta-analysis showed that overall tacrolimus is more effective at inducing complete renal remission than IVCYC (p=0.004), but the …
Efficacy and Safety of Lenabasum, a Cannabinoid Type 2 Receptor Agonist, in a Phase 3 Randomized Trial in Diffuse Cutaneous Systemic Sclerosis.
Spiera R, Kuwana M, Khanna D, Hummers L, Frech TM, Stevens W, Matucci-Cerinic M, Kafaja S, Distler O, Jun JB, Levy Y, Leszcyzński P, Gordon J, Steen V, Lee EB, Jankowski T, Litinsky I, Chung L, Hsu V, Mayes M, Sandorfi N, Simms RW, Finzel S, de Vries-Bouwstra J, Constantine S, Dgetluck N, Dinh Q, Bloom BJ, Furst DE, White B, Denton CP; RESOLVE-1 Study Group. Spiera R, et al. Arthritis Rheumatol. 2023 Sep;75(9):1608-1618. doi: 10.1002/art.42510. Epub 2023 Jun 15. Arthritis Rheumatol. 2023. PMID: 37098795 Free article. Clinical Trial.
RESULTS: The primary end point, the American College of Rheumatology combined response index in dcSSc (CRISS) at week 52 for lenabasum 20 mg twice a day versus placebo, was not met, with CRISS score of 0.888 versus 0.887 (P = 0.4972, using mixed models repeated measures [M …
RESULTS: The primary end point, the American College of Rheumatology combined response index in dcSSc (CRISS) at week 52 for lenabasum 20 mg …
Exploring the relationship between metal exposure, BDNF, and behavior in adolescent males.
Rodríguez-Carrillo A, Mustieles V, D'Cruz SC, Legoff L, Gil F, Olmedo P, Reina-Pérez I, Mundo A, Molina M, Smagulova F, David A, Freire C, Fernández MF. Rodríguez-Carrillo A, et al. Int J Hyg Environ Health. 2022 Jan;239:113877. doi: 10.1016/j.ijheh.2021.113877. Epub 2021 Oct 28. Int J Hyg Environ Health. 2022. PMID: 34757248 Free article.
The percentage BDNF DNA methylation at CPGs #5 and the mean percentage CpG methylation increased across As tertiles (p-trend = 0.04 and 0.03, respectively), while 2nd tertile and 3rd tertile of Cd concentrations were associated with lower serum BDNF and higher CpG3 methyla …
The percentage BDNF DNA methylation at CPGs #5 and the mean percentage CpG methylation increased across As tertiles (p-trend = 0.04 a …
A nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer.
Goldberg M, Manzi A, Birdi A, Laporte B, Conway P, Cantin S, Mishra V, Singh A, Pearson AT, Goldberg ER, Goldberger S, Flaum B, Hasina R, London NR, Gallia GL, Bettegowda C, Young S, Sandulache V, Melville J, Shum J, O'Neill SE, Aydin E, Zhavoronkov A, Vidal A, Soto A, Alonso MJ, Rosenberg AJ, Lingen MW, D'Cruz A, Agrawal N, Izumchenko E. Goldberg M, et al. Nat Commun. 2022 Aug 17;13(1):4829. doi: 10.1038/s41467-022-31859-3. Nat Commun. 2022. PMID: 35977936 Free PMC article.
BDNF as a potential mediator between childhood BPA exposure and behavioral function in adolescent boys from the INMA-Granada cohort.
Mustieles V, Rodríguez-Carrillo A, Vela-Soria F, D'Cruz SC, David A, Smagulova F, Mundo-López A, Olivas-Martínez A, Reina-Pérez I, Olea N, Freire C, Arrebola JP, Fernández MF. Mustieles V, et al. Sci Total Environ. 2022 Jan 10;803:150014. doi: 10.1016/j.scitotenv.2021.150014. Epub 2021 Sep 1. Sci Total Environ. 2022. PMID: 34788942 Free article.
When independent variables were categorized in tertiles, positive dose-response associations were observed between BPA-thought problems (p-trend = 0.08), BPA-CpG6 (p-trend 0.01), and CpG6-thought problems (p-trend 0.01). ...
When independent variables were categorized in tertiles, positive dose-response associations were observed between BPA-thought problems ( …
Incidence and mortality of relapsing polychondritis in the UK: a population-based cohort study.
Hazra N, Dregan A, Charlton J, Gulliford MC, D'Cruz DP. Hazra N, et al. Rheumatology (Oxford). 2015 Dec;54(12):2181-7. doi: 10.1093/rheumatology/kev240. Epub 2015 Jul 17. Rheumatology (Oxford). 2015. PMID: 26187053
The standardized mortality ratio was 2.16 (95% CI 1.24, 3.51), P < 0.01. Respiratory disease, cardiac conditions and cancer were the most frequent causes of death. ...

The standardized mortality ratio was 2.16 (95% CI 1.24, 3.51), P < 0.01. Respiratory disease, cardiac conditions and cancer were t

…
Pregnancy outcome in patients with systemic vasculitis: a single-centre matched case-control study.
Sangle SR, Vounotrypidis P, Briley A, Nel L, Lutalo PM, Sanchez-Fernandez S, Chaib A, Salas-Manzanedo V, Shennan A, Khamashta MA, D'Cruz DP. Sangle SR, et al. Rheumatology (Oxford). 2015 Sep;54(9):1582-6. doi: 10.1093/rheumatology/kev018. Epub 2015 Mar 31. Rheumatology (Oxford). 2015. PMID: 25832613

RESULTS: Median gestational age at delivery was lower in the SV group: 36 weeks and 2 days (34-42) vs controls 40 (37-42) weeks (P < 0.03). Median birth weight in the SV group was 3.0 kg (2.0-5.2), whereas that of the controls was 3.5 (2.28-4.32) kg (P = 0.004).

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RESULTS: Median gestational age at delivery was lower in the SV group: 36 weeks and 2 days (34-42) vs controls 40 (37-42) weeks (P &l …
The prevalence of abnormal pulse wave velocity, pulse contour analysis and ankle-brachial index in patients with livedo reticularis: a controlled study.
Sangle SR, Tanikawa A, Schreiber K, Zakalka M, D'Cruz DP. Sangle SR, et al. Rheumatology (Oxford). 2013 Nov;52(11):1992-8. doi: 10.1093/rheumatology/ket227. Epub 2013 Jul 26. Rheumatology (Oxford). 2013. PMID: 23893524
Abnormal values of PWV in 10/41 (24.40%), ABPI in 4/41 (9.8%) and PCA in 10/41 (24.40%) patients were observed in the livedo group and in the non-livedo group abnormal values of PWV in 1/33 (P 0.025), ABPI in 0/33 (P = NS) and PCA in 5/33 (P = NS) were observ …
Abnormal values of PWV in 10/41 (24.40%), ABPI in 4/41 (9.8%) and PCA in 10/41 (24.40%) patients were observed in the livedo group and in th …