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Signaling abnormalities in systemic lupus erythematosus as potential drug targets.
Fernandez D, Bonilla E, Phillips P, Perl A. Fernandez D, et al. Endocr Metab Immune Disord Drug Targets. 2006 Dec;6(4):305-11. doi: 10.2174/187153006779025748. Endocr Metab Immune Disord Drug Targets. 2006. PMID: 17214576 Review.
SLE T-cells have persistently hyperpolarized mitochondria associated with increased mitochondrial mass, high levels of reactive oxygen species (ROS) and low levels of ATP, which decrease activation-induced apoptosis and instead predispose T cells for necrosis, thus stimula …
SLE T-cells have persistently hyperpolarized mitochondria associated with increased mitochondrial mass, high levels of reactive oxygen speci …
Ethanol metabolism by alcohol dehydrogenase or cytochrome P450 2E1 differentially impairs hepatic protein trafficking and growth hormone signaling.
Doody EE, Groebner JL, Walker JR, Frizol BM, Tuma DJ, Fernandez DJ, Tuma PL. Doody EE, et al. Among authors: fernandez dj. Am J Physiol Gastrointest Liver Physiol. 2017 Dec 1;313(6):G558-G569. doi: 10.1152/ajpgi.00027.2017. Epub 2017 Sep 1. Am J Physiol Gastrointest Liver Physiol. 2017. PMID: 28864499 Free PMC article.
Both enzymes metabolize ethanol into acetaldehyde, but CYP2E1 activity also results in the production of reactive oxygen species (ROS) that promote oxidative stress. We have previously shown that microtubules are hyperacetylated in ethanol-treated polarized, hepatic WIF-B …
Both enzymes metabolize ethanol into acetaldehyde, but CYP2E1 activity also results in the production of reactive oxygen species (ROS …