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T Cell Extracellular Traps: Tipping the Balance Between Skin Health and Disease.
Ouyang K, Oparaugo N, Nelson AM, Agak GW. Ouyang K, et al. Front Immunol. 2022 Jun 20;13:900634. doi: 10.3389/fimmu.2022.900634. eCollection 2022. Front Immunol. 2022. PMID: 35795664 Free PMC article. Review.
Here, we consider host-microbe ET interactions by highlighting how cutaneous T cell-derived ETs aid in orchestrating host immune responses against Cutibacterium acnes (C. acnes), a commensal skin bacterium that contributes to skin health, but is also associated with acne v …
Here, we consider host-microbe ET interactions by highlighting how cutaneous T cell-derived ETs aid in orchestrating host immune responses a …
RNA Editing of the Human DNA Glycosylase NEIL1 Alters Its Removal of 5-Hydroxyuracil Lesions in DNA.
Yeo J, Lotsof ER, Anderson-Steele BM, David SS. Yeo J, et al. Biochemistry. 2021 May 18;60(19):1485-1497. doi: 10.1021/acs.biochem.1c00062. Epub 2021 Apr 30. Biochemistry. 2021. PMID: 33929180 Free PMC article.
Both NEIL1 isoforms catalyzed low levels of 5-OHU excision in single-stranded DNA, bubble and bulge DNA contexts and in duplex DNA base paired with A. Removal of 5-OHU in base pairs with G, T, and C was found to be faster and proceed to a higher overall extent with UE than …
Both NEIL1 isoforms catalyzed low levels of 5-OHU excision in single-stranded DNA, bubble and bulge DNA contexts and in duplex DNA base pair …
Distinct gene expression program dynamics during erythropoiesis from human induced pluripotent stem cells compared with adult and cord blood progenitors.
Merryweather-Clarke AT, Tipping AJ, Lamikanra AA, Fa R, Abu-Jamous B, Tsang HP, Carpenter L, Robson KJ, Nandi AK, Roberts DJ. Merryweather-Clarke AT, et al. BMC Genomics. 2016 Oct 21;17(1):817. doi: 10.1186/s12864-016-3134-z. BMC Genomics. 2016. PMID: 27769165 Free PMC article.
We explored the function of differentially expressed genes in hiPSC-specific clusters defined by our novel tunable clustering algorithms (SMART and Bi-CoPaM). HiPSCs show reduced expression of c-KIT and key erythroid transcription factors SOX6, MYB and BCL11A, strong HBZ-i …
We explored the function of differentially expressed genes in hiPSC-specific clusters defined by our novel tunable clustering algorithms (SM …