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Page 1
Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis.
Wellenstein MD, Coffelt SB, Duits DEM, van Miltenburg MH, Slagter M, de Rink I, Henneman L, Kas SM, Prekovic S, Hau CS, Vrijland K, Drenth AP, de Korte-Grimmerink R, Schut E, van der Heijden I, Zwart W, Wessels LFA, Schumacher TN, Jonkers J, de Visser KE. Wellenstein MD, et al. Among authors: duits dem. Nature. 2019 Aug;572(7770):538-542. doi: 10.1038/s41586-019-1450-6. Epub 2019 Jul 31. Nature. 2019. PMID: 31367040 Free PMC article.
Neoadjuvant immune checkpoint blockade triggers persistent and systemic Treg activation which blunts therapeutic efficacy against metastatic spread of breast tumors.
Blomberg OS, Kos K, Spagnuolo L, Isaeva OI, Garner H, Wellenstein MD, Bakker N, Duits DEM, Kersten K, Klarenbeek S, Hau CS, Kaldenbach D, Raeven EAM, Vrijland K, Kok M, de Visser KE. Blomberg OS, et al. Among authors: duits dem. Oncoimmunology. 2023 Apr 13;12(1):2201147. doi: 10.1080/2162402X.2023.2201147. eCollection 2023. Oncoimmunology. 2023. PMID: 37089449 Free PMC article.
Tumor-expressed factor VII is associated with survival and regulates tumor progression in breast cancer.
Kroone C, Tieken C, Kocatürk B, Paauwe M, Blok EJ, Ünlü B, van den Berg YW, Stanganello E, Kapteijn MY, Swier N, Zhang X, Duits DEM, Lin Y, Oostenbrink LVE, van den Akker RFP, Mosnier LO, Hawinkels LJ, van Vlijmen BJM, Ruf W, Kuppen PJ, Cannegieter SC, Buijs JT, Versteeg HH. Kroone C, et al. Among authors: duits dem. Blood Adv. 2023 Jun 13;7(11):2388-2400. doi: 10.1182/bloodadvances.2022008455. Blood Adv. 2023. PMID: 36920782 Free PMC article.
Tumor-educated Tregs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche.
Kos K, Aslam MA, van de Ven R, Wellenstein MD, Pieters W, van Weverwijk A, Duits DEM, van Pul K, Hau CS, Vrijland K, Kaldenbach D, Raeven EAM, Quezada SA, Beyaert R, Jacobs H, de Gruijl TD, de Visser KE. Kos K, et al. Among authors: duits dem. Cell Rep. 2022 Mar 1;38(9):110447. doi: 10.1016/j.celrep.2022.110447. Cell Rep. 2022. PMID: 35235800 Free article.