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Invariant NKT cells metabolically adapt to the acute myeloid leukaemia environment.
Stavrou V, Fultang L, Booth S, De Simone D, Bartnik A, Scarpa U, Gneo L, Panetti S, Potluri S, Almowaled M, Barlow J, Jankevics A, Lloyd G, Southam A, Priestman DA, Cheng P, Dunn W, Platt F, Endou H, Craddock C, Keeshan K, Mussai F, De Santo C. Stavrou V, et al. Among authors: de simone d. Cancer Immunol Immunother. 2023 Mar;72(3):543-560. doi: 10.1007/s00262-022-03268-4. Epub 2022 Aug 13. Cancer Immunol Immunother. 2023. PMID: 35962843 Free PMC article.
Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Nav1.7 for the Treatment of Pain.
Adams GL, Pall PS, Grauer SM, Zhou X, Ballard JE, Vavrek M, Kraus RL, Morissette P, Li N, Colarusso S, Bianchi E, Palani A, Klein R, John CT, Wang D, Tudor M, Nolting AF, Biba M, Nowak T, Makarov AA, Reibarkh M, Buevich AV, Zhong W, Regalado EL, Wang X, Gao Q, Shahripour A, Zhu Y, de Simone D, Frattarelli T, Pasquini NM, Magotti P, Iaccarino R, Li Y, Solly K, Lee KJ, Wang W, Chen F, Zeng H, Wang J, Regan H, Amin RP, Regan CP, Burgey CS, Henze DA, Sun C, Tellers DM. Adams GL, et al. Among authors: de simone d. J Med Chem. 2022 Jan 13;65(1):485-496. doi: 10.1021/acs.jmedchem.1c01570. Epub 2021 Dec 21. J Med Chem. 2022. PMID: 34931831
Testing a Recombinant Form of Tetanus Toxoid as a Carrier Protein for Glycoconjugate Vaccines.
Oldrini D, Di Benedetto R, Carducci M, De Simone D, Massai L, Alfini R, Galli B, Brunelli B, Przedpelski A, Barbieri JT, Rossi O, Giannelli C, Rappuoli R, Berti F, Micoli F. Oldrini D, et al. Among authors: de simone d. Vaccines (Basel). 2023 Nov 28;11(12):1770. doi: 10.3390/vaccines11121770. Vaccines (Basel). 2023. PMID: 38140177 Free PMC article.
Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction.
Colarusso S, De Simone D, Frattarelli T, Andreini M, Cerretani M, Missineo A, Moretti D, Tambone S, Kempf G, Augustin M, Steinbacher S, Munoz-Sanjuan I, Park L, Summa V, Tomei L, Bresciani A, Dominguez C, Toledo-Sherman L, Bianchi E. Colarusso S, et al. Among authors: de simone d. Bioorg Med Chem. 2020 Nov 1;28(21):115738. doi: 10.1016/j.bmc.2020.115738. Epub 2020 Aug 30. Bioorg Med Chem. 2020. PMID: 33065433
Guiding Chemically Synthesized Peptide Drug Lead Optimization by Derisking Mast Cell Degranulation-Related Toxicities of a NaV1.7 Peptide Inhibitor.
Morissette P, Li N, Ballard JE, Vavrek M, Adams GL, Regan C, Regan H, Lee KJ, Wang W, Burton A, Chen F, Gerenser P, Li Y, Kraus RL, Tellers D, Palani A, Zhu Y, Sun C, Bianchi E, Colarusso S, De Simone D, Frattarelli T, Pasquini NM, Amin RP. Morissette P, et al. Among authors: de simone d. Toxicol Sci. 2022 Jan 24;185(2):170-183. doi: 10.1093/toxsci/kfab138. Toxicol Sci. 2022. PMID: 34897513
Development and Characterization of a Luminescence-Based High-Throughput Serum Bactericidal Assay (L-SBA) to Assess Bactericidal Activity of Human Sera against Nontyphoidal Salmonella.
Aruta MG, De Simone D, Dale H, Chirwa E, Kadwala I, Mbewe M, Banda H, Gordon M, Pizza M, Berlanda Scorza F, Nyirenda T, Canals R, Rossi O, On Behalf Of The Vacc-iNTS Consortium Collaborators. Aruta MG, et al. Among authors: de simone d. Methods Protoc. 2022 Dec 16;5(6):100. doi: 10.3390/mps5060100. Methods Protoc. 2022. PMID: 36548142 Free PMC article.
Characterization of Enzyme-Linked Immunosorbent Assay (ELISA) for Quantification of Antibodies against Salmonella Typhimurium and Salmonella Enteritidis O-Antigens in Human Sera.
Aruta MG, Lari E, De Simone D, Semplici B, Semplici C, Dale H, Chirwa E, Kadwala I, Mbewe M, Banda H, Iturriza-Gomara M, Gordon M, Nyirenda T, Piu P, Pizza M, Berlanda Scorza F, Grappi S, Canals R, Rossi O, On Behalf Of The Vacc-iNTS Consortium Collaborators. Aruta MG, et al. Among authors: de simone d. BioTech (Basel). 2023 Aug 11;12(3):54. doi: 10.3390/biotech12030054. BioTech (Basel). 2023. PMID: 37606441 Free PMC article.
O-Antigen decorations in Salmonella enterica play a key role in eliciting functional immune responses against heterologous serovars in animal models.
Gasperini G, Massai L, De Simone D, Raso MM, Palmieri E, Alfini R, Rossi O, Ravenscroft N, Kuttel MM, Micoli F. Gasperini G, et al. Among authors: de simone d. Front Cell Infect Microbiol. 2024 Feb 29;14:1347813. doi: 10.3389/fcimb.2024.1347813. eCollection 2024. Front Cell Infect Microbiol. 2024. PMID: 38487353 Free PMC article.