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Page 1
Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.
Blaazer AR, Singh AK, de Heuvel E, Edink E, Orrling KM, Veerman JJN, van den Bergh T, Jansen C, Balasubramaniam E, Mooij WJ, Custers H, Sijm M, Tagoe DNA, Kalejaiye TD, Munday JC, Tenor H, Matheeussen A, Wijtmans M, Siderius M, de Graaf C, Maes L, de Koning HP, Bailey DS, Sterk GJ, de Esch IJP, Brown DG, Leurs R. Blaazer AR, et al. Among authors: tagoe dna. J Med Chem. 2018 May 10;61(9):3870-3888. doi: 10.1021/acs.jmedchem.7b01670. Epub 2018 May 1. J Med Chem. 2018. PMID: 29672041 Free PMC article.
Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNA interference library screening for resistance to the phosphodiesterase inhibitor CpdA.
Gould MK, Bachmaier S, Ali JA, Alsford S, Tagoe DN, Munday JC, Schnaufer AC, Horn D, Boshart M, de Koning HP. Gould MK, et al. Among authors: tagoe dn. Antimicrob Agents Chemother. 2013 Oct;57(10):4882-93. doi: 10.1128/AAC.00508-13. Epub 2013 Jul 22. Antimicrob Agents Chemother. 2013. PMID: 23877697 Free PMC article.
Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy.
Alzahrani KJH, Ali JAM, Eze AA, Looi WL, Tagoe DNA, Creek DJ, Barrett MP, de Koning HP. Alzahrani KJH, et al. Among authors: tagoe dna. Int J Parasitol Drugs Drug Resist. 2017 Aug;7(2):206-226. doi: 10.1016/j.ijpddr.2017.04.003. Epub 2017 Apr 20. Int J Parasitol Drugs Drug Resist. 2017. PMID: 28453984 Free PMC article.
Functional analysis of drug resistance-associated mutations in the Trypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein.
Munday JC, Tagoe DN, Eze AA, Krezdorn JA, Rojas López KE, Alkhaldi AA, McDonald F, Still J, Alzahrani KJ, Settimo L, De Koning HP. Munday JC, et al. Among authors: tagoe dn. Mol Microbiol. 2015 May;96(4):887-900. doi: 10.1111/mmi.12979. Epub 2015 Mar 21. Mol Microbiol. 2015. PMID: 25708978 Free PMC article.