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Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection.
Ullah TR, Johansen MD, Balka KR, Ambrose RL, Gearing LJ, Roest J, Vivian JP, Sapkota S, Jayasekara WSN, Wenholz DS, Aldilla VR, Zeng J, Miemczyk S, Nguyen DH, Hansbro NG, Venkatraman R, Kang JH, Pang ES, Thomas BJ, Alharbi AS, Rezwan R, O'Keeffe M, Donald WA, Ellyard JI, Wong W, Kumar N, Kile BT, Vinuesa CG, Kelly GE, Laczka OF, Hansbro PM, De Nardo D, Gantier MP. Ullah TR, et al. Among authors: wenholz ds. Nat Commun. 2023 Sep 18;14(1):5666. doi: 10.1038/s41467-023-41381-9. Nat Commun. 2023. PMID: 37723181 Free PMC article.
Inhibitors of bacterial RNA polymerase transcription complex.
Wenholz DS, Miller M, Dawson C, Bhadbhade M, Black DS, Griffith R, Dinh H, Cain A, Lewis P, Kumar N. Wenholz DS, et al. Bioorg Chem. 2022 Jan;118:105481. doi: 10.1016/j.bioorg.2021.105481. Epub 2021 Nov 13. Bioorg Chem. 2022. PMID: 34801947
Small molecule inhibitors of bacterial transcription complex formation.
Wenholz DS, Zeng M, Ma C, Mielczarek M, Yang X, Bhadbhade M, Black DSC, Lewis PJ, Griffith R, Kumar N. Wenholz DS, et al. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4302-4308. doi: 10.1016/j.bmcl.2017.08.036. Epub 2017 Aug 19. Bioorg Med Chem Lett. 2017. PMID: 28866270