There has been a resurgence of interest in surgical treatment of Parkinson's disease in the past five years due to the large number of patients who have medically intractable symptoms and because significant improvements in neuroimaging and stereotactic techniques have made surgical procedures safer and more accurate. Stereotactic pallidotomy procedures allow neurosurgeons to destroy a portion of the globus pallidus, and thereby, decrease patients' muscle rigidity from Parkinson's disease. These surgical procedures primarily involve magnetic resonance-guided stereotactic targeting and microelectrode recording techniques. To ensure successful patient outcomes, stereotactic pallidotomy procedures require special perioperative nursing interventions discussed in this article.