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Oral treatment with the all-d-peptide RD2 enhances cognition in aged beagle dogs - A model of sporadic Alzheimer's disease.
Kutzsche J, Schemmert S, Bujnicki T, Zafiu C, Halbgebauer S, Kraemer-Schulien V, Pils M, Blömeke L, Post J, Kulawik A, Jürgens D, Rossberg WM, Hümpel M, Bannach O, Otto M, Araujo JA, Willuweit A, Willbold D. Kutzsche J, et al. Among authors: jurgens d. Heliyon. 2023 Jul 29;9(8):e18443. doi: 10.1016/j.heliyon.2023.e18443. eCollection 2023 Aug. Heliyon. 2023. PMID: 37609390 Free PMC article.
Aβ oligomer eliminating compounds interfere successfully with pEAβ(3-42) induced motor neurodegenerative phenotype in transgenic mice.
Dunkelmann T, Teichmann K, Ziehm T, Schemmert S, Frenzel D, Tusche M, Dammers C, Jürgens D, Langen KJ, Demuth HU, Shah NJ, Kutzsche J, Willuweit A, Willbold D. Dunkelmann T, et al. Among authors: jurgens d. Neuropeptides. 2018 Feb;67:27-35. doi: 10.1016/j.npep.2017.11.011. Epub 2017 Nov 27. Neuropeptides. 2018. PMID: 29273382
Safety and pharmacokinetics of the orally available antiprionic compound PRI-002: A single and multiple ascending dose phase I study.
Kutzsche J, Jürgens D, Willuweit A, Adermann K, Fuchs C, Simons S, Windisch M, Hümpel M, Rossberg W, Wolzt M, Willbold D. Kutzsche J, et al. Among authors: jurgens d. Alzheimers Dement (N Y). 2020 Mar 20;6(1):e12001. doi: 10.1002/trc2.12001. eCollection 2020. Alzheimers Dement (N Y). 2020. PMID: 32211506 Free PMC article.
QIAD assay for quantitating a compound's efficacy in elimination of toxic Aβ oligomers.
Brener O, Dunkelmann T, Gremer L, van Groen T, Mirecka EA, Kadish I, Willuweit A, Kutzsche J, Jürgens D, Rudolph S, Tusche M, Bongen P, Pietruszka J, Oesterhelt F, Langen KJ, Demuth HU, Janssen A, Hoyer W, Funke SA, Nagel-Steger L, Willbold D. Brener O, et al. Among authors: jurgens d. Sci Rep. 2015 Sep 23;5:13222. doi: 10.1038/srep13222. Sci Rep. 2015. PMID: 26394756 Free PMC article.