Labile assembly of a tardigrade protein induces biostasis.
Sanchez-Martinez S, Nguyen K, Biswas S, Nicholson V, Romanyuk AV, Ramirez J, Kc S, Akter A, Childs C, Meese EK, Usher ET, Ginell GM, Yu F, Gollub E, Malferrari M, Francia F, Venturoli G, Martin EW, Caporaletti F, Giubertoni G, Woutersen S, Sukenik S, Woolfson DN, Holehouse AS, Boothby TC.
Sanchez-Martinez S, et al.
Protein Sci. 2024 Apr;33(4):e4941. doi: 10.1002/pro.4941.
Protein Sci. 2024.
PMID: 38501490
Free PMC article.
Here we report a mechanism of fibrillization and gelation for CAHS D similar to that of intermediate filament assembly. We show that in vitro, gelation restricts molecular motion, immobilizing and protecting labile material from the harmful effects of drying. In vivo, we o …
Here we report a mechanism of fibrillization and gelation for CAHS D similar to that of intermediate filament assembly. We show that …