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Page 1
Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning.
Haber L, Olson K, Kelly MP, Crawford A, DiLillo DJ, Tavaré R, Ullman E, Mao S, Canova L, Sineshchekova O, Finney J, Pawashe A, Patel S, McKay R, Rizvi S, Damko E, Chiu D, Vazzana K, Ram P, Mohrs K, D'Orvilliers A, Xiao J, Makonnen S, Hickey C, Arnold C, Giurleo J, Chen YP, Thwaites C, Dudgeon D, Bray K, Rafique A, Huang T, Delfino F, Hermann A, Kirshner JR, Retter MW, Babb R, MacDonald D, Chen G, Olson WC, Thurston G, Davis S, Lin JC, Smith E. Haber L, et al. Sci Rep. 2021 Jul 13;11(1):14397. doi: 10.1038/s41598-021-93842-0. Sci Rep. 2021. PMID: 34257348 Free PMC article.
Spatial analyses of immune cell infiltration in cancer: current methods and future directions: A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer.
Page DB, Broeckx G, Jahangir CA, Verbandt S, Gupta RR, Thagaard J, Khiroya R, Kos Z, Abduljabbar K, Acosta Haab G, Acs B, Akturk G, Almeida JS, Alvarado-Cabrero I, Azmoudeh-Ardalan F, Badve S, Baharun NB, Bellolio ER, Bheemaraju V, Blenman KR, Botinelly Mendonça Fujimoto L, Bouchmaa N, Burgues O, Cheang MCU, Ciompi F, Cooper LA, Coosemans A, Corredor G, Dantas Portela FL, Deman F, Demaria S, Dudgeon SN, Elghazawy M, Ely S, Fernandez-Martín C, Fineberg S, Fox SB, Gallagher WM, Giltnane JM, Gnjatic S, Gonzalez-Ericsson PI, Grigoriadis A, Halama N, Hanna MG, Harbhajanka A, Hardas A, Hart SN, Hartman J, Hewitt S, Hida AI, Horlings HM, Husain Z, Hytopoulos E, Irshad S, Janssen EA, Kahila M, Kataoka TR, Kawaguchi K, Kharidehal D, Khramtsov AI, Kiraz U, Kirtani P, Kodach LL, Korski K, Kovács A, Laenkholm AV, Lang-Schwarz C, Larsimont D, Lennerz JK, Lerousseau M, Li X, Ly A, Madabhushi A, Maley SK, Manur Narasimhamurthy V, Marks DK, McDonald ES, Mehrotra R, Michiels S, Minhas FUAA, Mittal S, Moore DA, Mushtaq S, Nighat H, Papathomas T, Penault-Llorca F, Perera RD, Pinard CJ, Pinto-Cardenas JC, Pruneri G, Pusztai L, Rahman A, Rajpoot NM, Rapoport BL, Rau TT, Reis-Filho JS, Ribeiro JM, Rimm… See abstract for full author list ➔ Page DB, et al. J Pathol. 2023 Aug;260(5):514-532. doi: 10.1002/path.6165. Epub 2023 Aug 23. J Pathol. 2023. PMID: 37608771 Review.
Pitfalls in machine learning-based assessment of tumor-infiltrating lymphocytes in breast cancer: A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer.
Thagaard J, Broeckx G, Page DB, Jahangir CA, Verbandt S, Kos Z, Gupta R, Khiroya R, Abduljabbar K, Acosta Haab G, Acs B, Akturk G, Almeida JS, Alvarado-Cabrero I, Amgad M, Azmoudeh-Ardalan F, Badve S, Baharun NB, Balslev E, Bellolio ER, Bheemaraju V, Blenman KR, Botinelly Mendonça Fujimoto L, Bouchmaa N, Burgues O, Chardas A, Chon U Cheang M, Ciompi F, Cooper LA, Coosemans A, Corredor G, Dahl AB, Dantas Portela FL, Deman F, Demaria S, Doré Hansen J, Dudgeon SN, Ebstrup T, Elghazawy M, Fernandez-Martín C, Fox SB, Gallagher WM, Giltnane JM, Gnjatic S, Gonzalez-Ericsson PI, Grigoriadis A, Halama N, Hanna MG, Harbhajanka A, Hart SN, Hartman J, Hauberg S, Hewitt S, Hida AI, Horlings HM, Husain Z, Hytopoulos E, Irshad S, Janssen EA, Kahila M, Kataoka TR, Kawaguchi K, Kharidehal D, Khramtsov AI, Kiraz U, Kirtani P, Kodach LL, Korski K, Kovács A, Laenkholm AV, Lang-Schwarz C, Larsimont D, Lennerz JK, Lerousseau M, Li X, Ly A, Madabhushi A, Maley SK, Manur Narasimhamurthy V, Marks DK, McDonald ES, Mehrotra R, Michiels S, Minhas FUAA, Mittal S, Moore DA, Mushtaq S, Nighat H, Papathomas T, Penault-Llorca F, Perera RD, Pinard CJ, Pinto-Cardenas JC, Pruneri G, Pusztai L, Rahman A, Rajpoot NM, … See abstract for full author list ➔ Thagaard J, et al. J Pathol. 2023 Aug;260(5):498-513. doi: 10.1002/path.6155. Epub 2023 Aug 23. J Pathol. 2023. PMID: 37608772 Free PMC article. Review.
The Evolution of Tumors in Mice and Humans with Germline p53 Mutations.
Levine AJ, Chan CS, Dudgeon C, Puzio-Kuter A, Hainaut P. Levine AJ, et al. Cold Spring Harb Symp Quant Biol. 2015;80:139-45. doi: 10.1101/sqb.2015.80.027631. Epub 2015 Dec 7. Cold Spring Harb Symp Quant Biol. 2015. PMID: 26642854 Review.
After that, the T-cell clone selects gene amplifications in cyclin D and cdk-6, and in Ikaros in the Notch pathway. Humans heterozygous for the p53 mutant gene in the germline (Li-Fraumeni syndrome) develop cancers at an early age. ...
After that, the T-cell clone selects gene amplifications in cyclin D and cdk-6, and in Ikaros in the Notch pathway. Humans heterozygo …
The need to research refractory breathlessness.
Currow DC, Abernethy AP, Allcroft P, Banzett RB, Bausewein C, Booth S, Carrieri-Kohlman V, Davidson P, Disler R, Donesky D, Dudgeon D, Ekstrom M, Farquhar M, Higginson I, Janssen D, Jensen D, Jolley C, Krajnik M, Laveneziana P, McDonald C, Maddocks M, Morelot-Panzini C, Moxham J, Mularski RA, Noble S, O'Donnell D, Parshall MB, Pattinson K, Phillips J, Ross J, Schwartzstein RM, Similowski T, Simon ST, Smith T, Wells A, Yates P, Yorke J, Johnson MJ. Currow DC, et al. Eur Respir J. 2016 Jan;47(1):342-3. doi: 10.1183/13993003.00653-2015. Eur Respir J. 2016. PMID: 26721965 Free article. No abstract available.
Immuno-PET Monitoring of Lymphocytes Using the CD8-Specific Antibody REGN5054.
Tavaré R, Danton M, Giurleo JT, Makonnen S, Hickey C, Arnold TC, Kelly MP, Fredriksson F, Bruestle K, Hermann A, Ullman E, Edelmann KH, Potocky T, Dudgeon D, Bhatt NB, Doubrovin M, Barry T, Kyratsous CA, Gurer C, Tu N, Gartner H, Murphy A, Macdonald LE, Popke J, Mintz A, Griesemer A, Olson WC, Thurston G, Ma D, Kirshner JR. Tavaré R, et al. Cancer Immunol Res. 2022 Oct 4;10(10):1190-1209. doi: 10.1158/2326-6066.CIR-21-0405. Cancer Immunol Res. 2022. PMID: 35895745 Free PMC article.
Compensatory recruitment allows amphibian population persistence in anthropogenic habitats.
Cayuela H, Monod-Broca B, Lemaître JF, Besnard A, Gippet JMW, Schmidt BR, Romano A, Hertach T, Angelini C, Canessa S, Rosa G, Vignoli L, Venchi A, Carafa M, Giachi F, Tiberi A, Hantzschmann AM, Sinsch U, Tournier E, Bonnaire E, Gollmann G, Gollmann B, Spitzen-van der Sluijs A, Buschmann H, Kinet T, Laudelout A, Fonters R, Bunz Y, Corail M, Biancardi C, Di Cerbo AR, Langlois D, Thirion JM, Bernard L, Boussiquault E, Doré F, Leclerc T, Enderlin N, Laurenceau F, Morin L, Skrzyniarz M, Barrioz M, Morizet Y, Cruickshank SS, Pichenot J, Maletzky A, Delsinne T, Henseler D, Aumaître D, Gailledrat M, Moquet J, Veen R, Krijnen P, Rivière L, Trenti M, Endrizzi S, Pedrini P, Biaggini M, Vanni S, Dudgeon D, Gaillard JM, Léna JP. Cayuela H, et al. Proc Natl Acad Sci U S A. 2022 Sep 20;119(38):e2206805119. doi: 10.1073/pnas.2206805119. Epub 2022 Sep 12. Proc Natl Acad Sci U S A. 2022. PMID: 36095177 Free PMC article.
A global agenda for advancing freshwater biodiversity research.
Maasri A, Jähnig SC, Adamescu MC, Adrian R, Baigun C, Baird DJ, Batista-Morales A, Bonada N, Brown LE, Cai Q, Campos-Silva JV, Clausnitzer V, Contreras-MacBeath T, Cooke SJ, Datry T, Delacámara G, De Meester L, Dijkstra KB, Do VT, Domisch S, Dudgeon D, Erös T, Freitag H, Freyhof J, Friedrich J, Friedrichs-Manthey M, Geist J, Gessner MO, Goethals P, Gollock M, Gordon C, Grossart HP, Gulemvuga G, Gutiérrez-Fonseca PE, Haase P, Hering D, Hahn HJ, Hawkins CP, He F, Heino J, Hermoso V, Hogan Z, Hölker F, Jeschke JM, Jiang M, Johnson RK, Kalinkat G, Karimov BK, Kasangaki A, Kimirei IA, Kohlmann B, Kuemmerlen M, Kuiper JJ, Kupilas B, Langhans SD, Lansdown R, Leese F, Magbanua FS, Matsuzaki SS, Monaghan MT, Mumladze L, Muzon J, Mvogo Ndongo PA, Nejstgaard JC, Nikitina O, Ochs C, Odume ON, Opperman JJ, Patricio H, Pauls SU, Raghavan R, Ramírez A, Rashni B, Ross-Gillespie V, Samways MJ, Schäfer RB, Schmidt-Kloiber A, Seehausen O, Shah DN, Sharma S, Soininen J, Sommerwerk N, Stockwell JD, Suhling F, Tachamo Shah RD, Tharme RE, Thorp JH, Tickner D, Tockner K, Tonkin JD, Valle M, Vitule J, Volk M, Wang D, Wolter C, Worischka S. Maasri A, et al. Ecol Lett. 2022 Feb;25(2):255-263. doi: 10.1111/ele.13931. Epub 2021 Dec 1. Ecol Lett. 2022. PMID: 34854211 Free article.
Rapid prediction of expression and refolding yields using phage display.
Dudgeon K, Rouet R, Christ D. Dudgeon K, et al. Protein Eng Des Sel. 2013 Oct;26(10):671-4. doi: 10.1093/protein/gzt019. Epub 2013 May 19. Protein Eng Des Sel. 2013. PMID: 23690626
We have recently identified mutations that control the aggregation behavior of human antibody variable domains (Dudgeon K., Rouet R., Kokmeijer I., Schofield P., Stolp J., Langley D., Stock D. and Christ D. (2012) Proc Natl Acad Sci USA, 109, 10879-108 …
We have recently identified mutations that control the aggregation behavior of human antibody variable domains (Dudgeon K., Rouet R., …
44 results