Novel Benzotriazole-β-lactam Derivatives as Antimalarial Agents: Design, Synthesis, Biological Evaluation and Molecular Docking Studies.
Aye M, Jarrahpour A, Haghighijoo Z, Heiran R, Pournejati R, Karbalaei-Heidari HR, Sinou V, Brunel JM, Akkurt M, Özdemir N, Turos E.
Aye M, et al.
Chem Biodivers. 2024 Feb;21(2):e202301745. doi: 10.1002/cbdv.202301745. Epub 2024 Feb 1.
Chem Biodivers. 2024.
PMID: 38192127
Herein, we designed and synthesized some structurally novel benzotriazole-beta-lactams using 2-(1H-benzo[d][1,2,3]triazol-1-yl)acetic acid as a key intermediate. To synthesize the target molecules, the ketene-imine cycloaddition reaction was employed. First, The reaction o …
Herein, we designed and synthesized some structurally novel benzotriazole-beta-lactams using 2-(1H-benzo[d][1,2,3]triazol-1-yl)acetic …