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2017 | 1 |
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Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain.
Nat Commun. 2017 May 12;8:15231. doi: 10.1038/ncomms15231.
Nat Commun. 2017.
PMID: 28497792
Free PMC article.
Additionally, we show the human CTD is also structurally heterogeneous and able to substitute for the D. melanogaster CTD in supporting fly development to adulthood. ...
Additionally, we show the human CTD is also structurally heterogeneous and able to substitute for the D. melanogaster CTD in supporti …
Dynamic origins of differential RNA binding function in two dsRBDs from the miRNA "microprocessor" complex.
Wostenberg C, Quarles KA, Showalter SA.
Wostenberg C, et al. Among authors: showalter sa.
Biochemistry. 2010 Dec 21;49(50):10728-36. doi: 10.1021/bi1015716. Epub 2010 Nov 22.
Biochemistry. 2010.
PMID: 21073201
Free PMC article.
The study was motivated by electrophoretic mobility shift assays (EMSAs) of the two dsRBDs, which showed that Drosha-dsRBD does not bind a representative miRNA but isolated DGCR8-dsRBD1 does (K(d) = 9.4 0.4 muM). Our results show that loop 2 in both dsRBDs is highly dynami …
The study was motivated by electrophoretic mobility shift assays (EMSAs) of the two dsRBDs, which showed that Drosha-dsRBD does not bind a r …
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