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(177)Lu-DOTA-Tyr(3)-c(Cys-Tyr-Trp-Lys-Thr-Cys)-Thr-Lys(cypate)-NH(2).
Zhang H. Zhang H. 2008 Mar 20 [updated 2008 Apr 22]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2008 Mar 20 [updated 2008 Apr 22]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641372 Free Books & Documents. Review.
For example, octreotide, a SST analog with a peptide sequence of eight amino acids (D-Phe-c(Cys-Tyr-D-Trp-Lys-Thr-Cys)-Thr(ol)), possesses a much higher affinity (~2 nM) binding to SSTR-2, -3, and -5 than binding to SSTR-1 and -4 (>1,000 nM). In addition t …
For example, octreotide, a SST analog with a peptide sequence of eight amino acids (D-Phe-c(Cys-Tyr-D-Trp-Lys-Thr-Cys)- …
Glycophorin-C sialylation regulates Lu/BCAM adhesive capacity during erythrocyte aging.
Klei TRL, de Back DZ, Asif PJ, Verkuijlen PJJH, Veldthuis M, Ligthart PC, Berghuis J, Clifford E, Beuger BM, van den Berg TK, van Zwieten R, El Nemer W, van Bruggen R. Klei TRL, et al. Blood Adv. 2018 Jan 3;2(1):14-24. doi: 10.1182/bloodadvances.2017013094. eCollection 2018 Jan 9. Blood Adv. 2018. PMID: 29344581 Free PMC article.
Following loss of sialic acid during erythrocyte aging, Lu/BCAM is released from glycophorin-C and allowed to interact with sialic acid residues on laminin-alpha5. Decreased glycophorin-C sialylation, as observed in individuals lacking exon 3 of glycophorin- …
Following loss of sialic acid during erythrocyte aging, Lu/BCAM is released from glycophorin-C and allowed to interact with si …
Steering Lu(3)N clusters in C(76-78) cages: cluster configuration dominated by cage transformation.
Yu P, Hu S, Tian X, Shen W, Yu P, Guo K, Xie Y, Bao L, Lu X. Yu P, et al. Nanoscale. 2022 Dec 1;14(46):17290-17296. doi: 10.1039/d2nr05049h. Nanoscale. 2022. PMID: 36377636
For this purpose, we herein synthesized three metallofullerene molecules with an easy-to-compare cluster configuration and cage arrangement, namely Lu(3)N@C(s)(17 490)-C(76), Lu(3)N@C(2)(22 010)-C(78), and Lu(3)N@D(3h)(5)- …
For this purpose, we herein synthesized three metallofullerene molecules with an easy-to-compare cluster configuration and cage arrangement, …
Fibroblast activation protein targeted radiotherapy induces an immunogenic tumor microenvironment and enhances the efficacy of PD-1 immune checkpoint inhibition.
Zboralski D, Osterkamp F, Christensen E, Bredenbeck A, Schumann A, Hoehne A, Schneider E, Paschke M, Ungewiss J, Haase C, Robillard L, Simmons AD, Harding TC, Nguyen M. Zboralski D, et al. Eur J Nucl Med Mol Imaging. 2023 Jul;50(9):2621-2635. doi: 10.1007/s00259-023-06211-6. Epub 2023 Apr 22. Eur J Nucl Med Mol Imaging. 2023. PMID: 37086273 Free PMC article.
METHODS: C57BL/6 mice bearing MCA205 mouse FAP-expressing tumors (MCA205-mFAP) were treated with (177)Lu-FAP-2287, anti-PD-1, or both. Tumor uptake of (177)Lu- FAP-2287 was assessed by SPECT/CT scanning, while therapeutic efficacy was measured by tumor volume and su …
METHODS: C57BL/6 mice bearing MCA205 mouse FAP-expressing tumors (MCA205-mFAP) were treated with (177)Lu-FAP-2287, anti-PD-1, or both …
[(68)Ga]Ga/[(177)Lu]Lu-BL01, a Novel Theranostic Pair for Targeting C-X-C Chemokine Receptor 4.
Lau J, Kwon D, Rousseau E, Zhang Z, Zeisler J, Uribe CF, Kuo HT, Zhang C, Lin KS, Bénard F. Lau J, et al. Mol Pharm. 2019 Nov 4;16(11):4688-4695. doi: 10.1021/acs.molpharmaceut.9b00808. Epub 2019 Oct 4. Mol Pharm. 2019. PMID: 31545614
C-X-C chemokine receptor type 4 (CXCR4) is overexpressed in hematological and solid malignancies. ...Methods: BL01 was synthesized by solid phase approach. A Lys(ivDde) residue was added at the C-terminus of LY2510924 (cyclo[Phe-Tyr-Lys(iPr)-d-Arg-2-Na …
C-X-C chemokine receptor type 4 (CXCR4) is overexpressed in hematological and solid malignancies. ...Methods: BL01 was synthes …
Crystallographic characterization of Lu(2)C(2n) (2n = 76-90): cluster selection by cage size.
Shen W, Bao L, Hu S, Yang L, Jin P, Xie Y, Akasaka T, Lu X. Shen W, et al. Chem Sci. 2018 Oct 30;10(3):829-836. doi: 10.1039/c8sc03886d. eCollection 2019 Jan 21. Chem Sci. 2018. PMID: 30774877 Free PMC article.
The molecular structures of these compounds are unambiguously assigned as Lu(2)@T (d)(2)-C(76), Lu(2)@D (3h)(5)-C(78), Lu(2)@C (2v)(5)-C(80), Lu(2)@C (2v)(7)-C(84), Lu(2)@C (s)(8)- …
The molecular structures of these compounds are unambiguously assigned as Lu(2)@T (d)(2)-C(76), Lu(2)@D ( …
Adamantylidene Addition to M(3) N@I(h) -C(80) (M=Sc, Lu) and Sc(3) N@D(5h) -C(80) : Synthesis and Crystallographic Characterization of the [5,6]-Open and [6,6]-Open Adducts.
Yamada M, Abe T, Saito C, Yamazaki T, Sato S, Mizorogi N, Slanina Z, Uhlík F, Suzuki M, Maeda Y, Lian Y, Lu X, Olmstead MM, Balch AL, Nagase S, Akasaka T. Yamada M, et al. Chemistry. 2017 May 11;23(27):6552-6561. doi: 10.1002/chem.201700049. Epub 2017 Mar 24. Chemistry. 2017. PMID: 28145046
Additions of adamantylidene (Ad) to M(3) N@I(h) -C(80) (M=Sc, Lu) and Sc(3) N@D(5h) -C(80) have been accomplished by photochemical reactions with 2-adamantyl-2,3'-[3H]-diazirine (1). ...In Sc(3) N@D(5h) -C(80) , the addition also proceede …
Additions of adamantylidene (Ad) to M(3) N@I(h) -C(80) (M=Sc, Lu) and Sc(3) N@D(5h) -C(80) have been accomplishe …
Lu AF35700 reverses the phencyclidine-induced disruption of thalamo-cortical activity by blocking dopamine D(1) and D(2) receptors.
Riga MS, Paz V, Didriksen M, Celada P, Artigas F. Riga MS, et al. Eur J Pharmacol. 2023 Aug 15;953:175802. doi: 10.1016/j.ejphar.2023.175802. Epub 2023 Jun 7. Eur J Pharmacol. 2023. PMID: 37295763
Here, we examined the ability of Lu AF35700 (preferential D(1)-R>D(2)-R antagonist), to reverse the alterations in thalamo-cortical activity induced by phencyclidine (PCP), used as a pharmacological model of schizophrenia. ...Likewise, Lu AF35700 pr …
Here, we examined the ability of Lu AF35700 (preferential D(1)-R>D(2)-R antagonist), to reverse the alterations in t …
Analysis of barley mutants ert-c.1 and ert-d.7 reveals two loci with additive effect on plant architecture.
Lu Q, Dockter C, Sirijovski N, Zakhrabekova S, Lundqvist U, Gregersen PL, Hansson M. Lu Q, et al. Planta. 2021 Jun 20;254(1):9. doi: 10.1007/s00425-021-03653-w. Planta. 2021. PMID: 34148131 Free PMC article.
Mutant ert-d.7 is an Ert-c Ert-d double mutant. Mutations in the Ert-c and Ert-d loci are among the most common barley mutations affecting plant architecture. ...Combined, mutations in Ert-c and Ert-d cause a pyramid-dense spike ph …
Mutant ert-d.7 is an Ert-c Ert-d double mutant. Mutations in the Ert-c and Ert-d loci are among the most …
[(177)Lu-DOTA](0)-D-Phe(1)-Tyr(3)-Octreotide ((177)Lu-DOTATOC) For Peptide Receptor Radiotherapy in Patients with Advanced Neuroendocrine Tumours: A Phase-II Study.
Baum RP, Kluge AW, Kulkarni H, Schorr-Neufing U, Niepsch K, Bitterlich N, van Echteld CJ. Baum RP, et al. Theranostics. 2016 Feb 13;6(4):501-10. doi: 10.7150/thno.13702. eCollection 2016. Theranostics. 2016. PMID: 26941843 Free PMC article. Clinical Trial.
In patients receiving more than one cycle, mean follow-up time was 22.4 11.0 months for all NETs (B) and PFS was 32.0 months for all NETs (B), 34.5 months for GEP-NET (C), and 11.9 months for other NETs (D). Objective response rates (Complete/Partial Responses) were …
In patients receiving more than one cycle, mean follow-up time was 22.4 11.0 months for all NETs (B) and PFS was 32.0 months for all NETs (B …
7,612 results