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The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids.
Desjardins EM, Smith BK, Day EA, Ducommun S, Sanders MJ, Nederveen JP, Ford RJ, Pinkosky SL, Townsend LK, Gutgesell RM, Lu R, Sakamoto K, Steinberg GR. Desjardins EM, et al. Proc Natl Acad Sci U S A. 2022 Nov 29;119(48):e2119824119. doi: 10.1073/pnas.2119824119. Epub 2022 Nov 21. Proc Natl Acad Sci U S A. 2022. PMID: 36409897 Free PMC article.
Identification of genetic risk loci and prioritization of genes and pathways for myasthenia gravis: a genome-wide association study.
Chia R, Saez-Atienzar S, Murphy N, Chiò A, Blauwendraat C; International Myasthenia Gravis Genomics Consortium; Roda RH, Tienari PJ, Kaminski HJ, Ricciardi R, Guida M, De Rosa A, Petrucci L, Evoli A, Provenzano C, Drachman DB, Traynor BJ. Chia R, et al. Proc Natl Acad Sci U S A. 2022 Feb 1;119(5):e2108672119. doi: 10.1073/pnas.2108672119. Proc Natl Acad Sci U S A. 2022. PMID: 35074870 Free PMC article.
Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats.
Latimer CS, Brewer LD, Searcy JL, Chen KC, Popović J, Kraner SD, Thibault O, Blalock EM, Landfield PW, Porter NM. Latimer CS, et al. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):E4359-66. doi: 10.1073/pnas.1404477111. Epub 2014 Sep 29. Proc Natl Acad Sci U S A. 2014. PMID: 25267625 Free PMC article.
Increasing evidence suggests that vitamin D may play a role in maintaining cognitive function and that vitamin D deficiency may accelerate age-related cognitive decline. Using aging rodents, we attempted to model the range of human serum vitamin D levels, fro …
Increasing evidence suggests that vitamin D may play a role in maintaining cognitive function and that vitamin D deficiency ma …
Trophic redundancy reduces vulnerability to extinction cascades.
Sanders D, Thébault E, Kehoe R, Frank van Veen FJ. Sanders D, et al. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2419-2424. doi: 10.1073/pnas.1716825115. Epub 2018 Feb 21. Proc Natl Acad Sci U S A. 2018. PMID: 29467292 Free PMC article.
Concerted reactions and mechanism of glucose pyrolysis and implications for cellulose kinetics.
Seshadri V, Westmoreland PR. Seshadri V, et al. J Phys Chem A. 2012 Dec 13;116(49):11997-2013. doi: 10.1021/jp3085099. Epub 2012 Nov 9. J Phys Chem A. 2012. PMID: 23082925
Concerted transition states, elementary-reaction pathways, and rate coefficients are computed for pyrolysis of beta-D-glucose (beta-D-glucopyranose), the monomer of cellulose, and for related molecules, giving an improved and elementary-reaction interpretation of th …
Concerted transition states, elementary-reaction pathways, and rate coefficients are computed for pyrolysis of beta-D-glucose (beta- …
Propagation of prions causing synucleinopathies in cultured cells.
Woerman AL, Stöhr J, Aoyagi A, Rampersaud R, Krejciova Z, Watts JC, Ohyama T, Patel S, Widjaja K, Oehler A, Sanders DW, Diamond MI, Seeley WW, Middleton LT, Gentleman SM, Mordes DA, Südhof TC, Giles K, Prusiner SB. Woerman AL, et al. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4949-58. doi: 10.1073/pnas.1513426112. Epub 2015 Aug 18. Proc Natl Acad Sci U S A. 2015. PMID: 26286986 Free PMC article.
In parallel studies, we fused alpha-synuclein to YFP to bioassay alpha-synuclein prions in the brains of patients who died of multiple system atrophy (MSA). Previously, MSA prion detection required 120 d for transmission into transgenic mice, whereas our cultured cell assa …
In parallel studies, we fused alpha-synuclein to YFP to bioassay alpha-synuclein prions in the brains of patients who died of multiple syste …
Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking.
George O, Sanders C, Freiling J, Grigoryan E, Vu S, Allen CD, Crawford E, Mandyam CD, Koob GF. George O, et al. Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18156-61. doi: 10.1073/pnas.1116523109. Epub 2012 Oct 15. Proc Natl Acad Sci U S A. 2012. PMID: 23071333 Free PMC article.
To address this issue, we examined FBJ murine osteosarcoma viral oncogene homolog (Fos) expression in the mPFC, CeA, hippocampus, and nucleus accumbens and evaluated working memory and anxiety-like behavior in rats given continuous (24 h/d for 7 d/wk) or intermitten …
To address this issue, we examined FBJ murine osteosarcoma viral oncogene homolog (Fos) expression in the mPFC, CeA, hippocampus, and nucleu …
Involvement of distinct arrestin-1 elements in binding to different functional forms of rhodopsin.
Zhuang T, Chen Q, Cho MK, Vishnivetskiy SA, Iverson TM, Gurevich VV, Sanders CR. Zhuang T, et al. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):942-7. doi: 10.1073/pnas.1215176110. Epub 2012 Dec 31. Proc Natl Acad Sci U S A. 2013. PMID: 23277586 Free PMC article.
Distinct sets of arrestin-1 elements were seen to be engaged by Rh* and inactive P-Rh, which induced conformational changes that differed from those triggered by binding of P-Rh*. Although arrestin-1 affinity for Rh* was seen to be low (K(D) > 150 muM), its affinity for …
Distinct sets of arrestin-1 elements were seen to be engaged by Rh* and inactive P-Rh, which induced conformational changes that differed fr …
16 results