Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation.
Yu M, Peng Z, Qin M, Liu Y, Wang J, Zhang C, Lin J, Dong T, Wang L, Li S, Yang Y, Xu S, Guo W, Zhang X, Shi M, Peng H, Luo X, Zhang H, Zhang L, Li Y, Yang XP, Sun S.
Yu M, et al.
Mol Cell. 2021 Mar 18;81(6):1216-1230.e9. doi: 10.1016/j.molcel.2021.01.010. Epub 2021 Feb 18.
Mol Cell. 2021.
PMID: 33606996
Free article.
Here, we report that IFN-gamma promotes nuclear translocation and phase separation of YAP after anti-PD-1 therapy in tumor cells. Hydrophobic interactions of the YAP coiled-coil domain mediate droplet initiation, and weak interactions of the intrinsically disordered region …
Here, we report that IFN-gamma promotes nuclear translocation and phase separation of YAP after anti-PD-1 therapy in tumor cells. Hydrophobi …