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Page 1
Gain- and Loss-of-Function CFTR Alleles Are Associated with COVID-19 Clinical Outcomes.
Baldassarri M, Zguro K, Tomati V, Pastorino C, Fava F, Croci S, Bruttini M, Picchiotti N, Furini S, Pedemonte N, Gabbi C, Renieri A, Fallerini C; Gen-Covid Multicenter Study. Baldassarri M, et al. Among authors: pastorino c. Cells. 2022 Dec 16;11(24):4096. doi: 10.3390/cells11244096. Cells. 2022. PMID: 36552859 Free PMC article.
Rescue by elexacaftor-tezacaftor-ivacaftor of the G1244E cystic fibrosis mutation's stability and gating defects are dependent on cell background.
Tomati V, Costa S, Capurro V, Pesce E, Pastorino C, Lena M, Sondo E, Di Duca M, Cresta F, Cristadoro S, Zara F, Galietta LJV, Bocciardi R, Castellani C, Lucanto MC, Pedemonte N. Tomati V, et al. Among authors: pastorino c. J Cyst Fibros. 2023 May;22(3):525-537. doi: 10.1016/j.jcf.2022.12.005. Epub 2022 Dec 19. J Cyst Fibros. 2023. PMID: 36543707
Partial Rescue of F508del-CFTR Stability and Trafficking Defects by Double Corrector Treatment.
Capurro V, Tomati V, Sondo E, Renda M, Borrelli A, Pastorino C, Guidone D, Venturini A, Giraudo A, Mandrup Bertozzi S, Musante I, Bertozzi F, Bandiera T, Zara F, Galietta LJV, Pedemonte N. Capurro V, et al. Among authors: pastorino c. Int J Mol Sci. 2021 May 17;22(10):5262. doi: 10.3390/ijms22105262. Int J Mol Sci. 2021. PMID: 34067708 Free PMC article.
Journey on VX-809-Based Hybrid Derivatives towards Drug-like F508del-CFTR Correctors: From Molecular Modeling to Chemical Synthesis and Biological Assays.
Parodi A, Righetti G, Pesce E, Salis A, Tomati V, Pastorino C, Tasso B, Benvenuti M, Damonte G, Pedemonte N, Cichero E, Millo E. Parodi A, et al. Among authors: pastorino c. Pharmaceuticals (Basel). 2022 Feb 23;15(3):274. doi: 10.3390/ph15030274. Pharmaceuticals (Basel). 2022. PMID: 35337072 Free PMC article.
The L467F-F508del Complex Allele Hampers Pharmacological Rescue of Mutant CFTR by Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis Patients: The Value of the Ex Vivo Nasal Epithelial Model to Address Non-Responders to CFTR-Modulating Drugs.
Sondo E, Cresta F, Pastorino C, Tomati V, Capurro V, Pesce E, Lena M, Iacomino M, Baffico AM, Coviello D, Bandiera T, Zara F, Galietta LJV, Bocciardi R, Castellani C, Pedemonte N. Sondo E, et al. Among authors: pastorino c. Int J Mol Sci. 2022 Mar 15;23(6):3175. doi: 10.3390/ijms23063175. Int J Mol Sci. 2022. PMID: 35328596 Free PMC article.