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Machine Learning-Based Virtual Screening for the Identification of Cdk5 Inhibitors.
Di Stefano M, Galati S, Ortore G, Caligiuri I, Rizzolio F, Ceni C, Bertini S, Bononi G, Granchi C, Macchia M, Poli G, Tuccinardi T. Di Stefano M, et al. Among authors: ceni c. Int J Mol Sci. 2022 Sep 13;23(18):10653. doi: 10.3390/ijms231810653. Int J Mol Sci. 2022. PMID: 36142566 Free PMC article.
Antioxidant-Conjugated 1,2,4-Triazolo[4,3-a]pyrazin-3-one Derivatives: Highly Potent and Selective Human A2A Adenosine Receptor Antagonists Possessing Protective Efficacy in Neuropathic Pain.
Falsini M, Catarzi D, Varano F, Ceni C, Dal Ben D, Marucci G, Buccioni M, Volpini R, Di Cesare Mannelli L, Lucarini E, Ghelardini C, Bartolucci G, Menicatti M, Colotta V. Falsini M, et al. Among authors: ceni c. J Med Chem. 2019 Sep 26;62(18):8511-8531. doi: 10.1021/acs.jmedchem.9b00778. Epub 2019 Sep 10. J Med Chem. 2019. PMID: 31453698
New 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives. Evaluation of different moieties on the 6-aryl ring to obtain potent and selective human A2A adenosine receptor antagonists.
Falsini M, Ceni C, Catarzi D, Varano F, Dal Ben D, Marucci G, Buccioni M, Martí Navia A, Volpini R, Colotta V. Falsini M, et al. Among authors: ceni c. Bioorg Med Chem Lett. 2020 Jun 1;30(11):127126. doi: 10.1016/j.bmcl.2020.127126. Epub 2020 Mar 24. Bioorg Med Chem Lett. 2020. PMID: 32241719
Discovery of first-in-class multi-target adenosine A2A receptor antagonists-carbonic anhydrase IX and XII inhibitors. 8-Amino-6-aryl-2-phenyl-1,2,4-triazolo [4,3-a]pyrazin-3-one derivatives as new potential antitumor agents.
Ceni C, Catarzi D, Varano F, Ben DD, Marucci G, Buccioni M, Volpini R, Angeli A, Nocentini A, Gratteri P, Supuran CT, Colotta V. Ceni C, et al. Eur J Med Chem. 2020 Sep 1;201:112478. doi: 10.1016/j.ejmech.2020.112478. Epub 2020 Jun 12. Eur J Med Chem. 2020. PMID: 32659606