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Showing results for donor gilt
Search for Conor Gill instead (2 results)
Expanding roles for GILT in immunity.
West LC, Cresswell P. West LC, et al. Curr Opin Immunol. 2013 Feb;25(1):103-8. doi: 10.1016/j.coi.2012.11.006. Epub 2012 Dec 12. Curr Opin Immunol. 2013. PMID: 23246037 Free PMC article. Review.
However, recent reports have greatly expanded our understanding of GILT's function. Several studies of GILT and antigen processing have shown that the influence of GILT on the peptide repertoire can alter the character of the immune response and affect centra …
However, recent reports have greatly expanded our understanding of GILT's function. Several studies of GILT and antigen proces …
GILT in tumor cells improves T cell-mediated anti-tumor immune surveillance.
Li H, Wang Y, Ma M, Hu L, Zhang X, Xin L, Zhang W, Sun X, Ren Y, Wang X, Yang J. Li H, et al. Immunol Lett. 2021 Jun;234:1-12. doi: 10.1016/j.imlet.2021.04.001. Epub 2021 Apr 7. Immunol Lett. 2021. PMID: 33838181
However, whether GILT expression in tumor cells can be associated with improved T cell-mediated anti-tumor responses remains unknown. ...These findings propose the boost of GILT-MHC-I axis in tumors as a viable option for immune system against cancer....
However, whether GILT expression in tumor cells can be associated with improved T cell-mediated anti-tumor responses remains unknown. …
Diverse cellular and organismal functions of the lysosomal thiol reductase GILT.
Rausch MP, Hastings KT. Rausch MP, et al. Mol Immunol. 2015 Dec;68(2 Pt A):124-8. doi: 10.1016/j.molimm.2015.06.008. Epub 2015 Jun 23. Mol Immunol. 2015. PMID: 26116226 Free PMC article. Review.
GILT expression in cancer cells is associated with improved patient survival. These diverse roles of GILT are discussed....
GILT expression in cancer cells is associated with improved patient survival. These diverse roles of GILT are discussed....
Expression of gilt acts as a positive regulator of mouse hematopoietic progenitor cells.
Broxmeyer HE, Cooper S, Blum JS. Broxmeyer HE, et al. Blood Cells Mol Dis. 2021 Sep;90:102574. doi: 10.1016/j.bcmd.2021.102574. Epub 2021 Apr 30. Blood Cells Mol Dis. 2021. PMID: 34015674 Free PMC article.
Herein, we demonstrate using gilt knockout (-/-) mice that loss of gilt associates with decreased numbers and cycling status of femoral hematopoietic progenitor cells (CFU-GM, BFU-E, and CFU-GEMM) with more modest effects on splenic progenitor cells. Thus, GILT …
Herein, we demonstrate using gilt knockout (-/-) mice that loss of gilt associates with decreased numbers and cycling status o …
The quality of porcine oocytes is affected by sexual maturity of the donor gilt.
Pawlak P, Renska N, Pers-Kamczyc E, Warzych E, Lechniak D. Pawlak P, et al. Reprod Biol. 2011 Mar;11(1):1-18. doi: 10.1016/s1642-431x(12)60060-6. Reprod Biol. 2011. PMID: 21455277
Interestingly, high quality oocytes displayed a similar level of apoptosis regardless of the donor puberty. We demonstrated that C gilts provided more BCB+ oocytes as well as more large oocytes than P gilts, although C-BCB+ oocytes showed higher apoptotic rate. ...
Interestingly, high quality oocytes displayed a similar level of apoptosis regardless of the donor puberty. We demonstrated that C gi …
GILT in Thymic Epithelial Cells Facilitates Central CD4 T Cell Tolerance to a Tissue-Restricted, Melanoma-Associated Self-Antigen.
Rausch MP, Meador LR, Metzger TC, Li H, Qiu S, Anderson MS, Hastings KT. Rausch MP, et al. J Immunol. 2020 Jun 1;204(11):2877-2886. doi: 10.4049/jimmunol.1900523. Epub 2020 Apr 8. J Immunol. 2020. PMID: 32269095 Free PMC article.
We found that GILT enhanced the negative selection of TRP1-specific thymocytes in mice. ...Thus, GILT expression in thymic APCs, and mTECs in particular, preferentially facilitates MHC class II-restricted presentation, negative selection, and increased Treg cells, r …
We found that GILT enhanced the negative selection of TRP1-specific thymocytes in mice. ...Thus, GILT expression in thymic APC …
GILT Expression in Human Melanoma Cells Enhances Generation of Antigenic Peptides for HLA Class II-Mediated Immune Recognition.
Hathaway-Schrader JD, Norton D, Hastings K, Doonan BP, Fritz ST, Bethard JR, Blum JS, Haque A. Hathaway-Schrader JD, et al. Int J Mol Sci. 2022 Jan 19;23(3):1066. doi: 10.3390/ijms23031066. Int J Mol Sci. 2022. PMID: 35162988 Free PMC article.
In the current study, we report that increased GILT expression generates a greater pool of antigenic peptides in melanoma cells for enhanced CD4+ T cell recognition. Our results suggest that the induction of GILT in human melanoma cells could aid in the development …
In the current study, we report that increased GILT expression generates a greater pool of antigenic peptides in melanoma cells for e …
Autophagy-dependent crosstalk between GILT and PAX-3 influences radiation sensitivity of human melanoma cells.
Hathaway-Schrader JD, Doonan BP, Hossain A, Radwan FFY, Zhang L, Haque A. Hathaway-Schrader JD, et al. J Cell Biochem. 2018 Feb;119(2):2212-2221. doi: 10.1002/jcb.26383. Epub 2017 Oct 18. J Cell Biochem. 2018. PMID: 28857256 Free PMC article.
Here we report that GILT expression inhibits a potential target, paired box-3 (PAX-3) protein, in late stage human metastatic melanoma. ...Confocal microscopic analysis demonstrated that GILT co-localizes with PAX-3 protein, but not with Daxx within melanoma cells. …
Here we report that GILT expression inhibits a potential target, paired box-3 (PAX-3) protein, in late stage human metastatic melanom …
Disulfide reduction in the endocytic pathway: immunological functions of gamma-interferon-inducible lysosomal thiol reductase.
Hastings KT, Cresswell P. Hastings KT, et al. Antioxid Redox Signal. 2011 Aug 1;15(3):657-68. doi: 10.1089/ars.2010.3684. Epub 2011 Apr 20. Antioxid Redox Signal. 2011. PMID: 21506690 Free PMC article. Review.
GILT can also facilitate the transfer of disulfide-containing antigens into the cytosol, enhancing their cross-presentation by MHC class I. ...In addition, GILT is conserved among lower eukaryotes and likely has additional functions. ...
GILT can also facilitate the transfer of disulfide-containing antigens into the cytosol, enhancing their cross-presentation by MHC cl …
GILT modulates CD4+ T-cell tolerance to the melanocyte differentiation antigen tyrosinase-related protein 1.
Rausch MP, Hastings KT. Rausch MP, et al. J Invest Dermatol. 2012 Jan;132(1):154-62. doi: 10.1038/jid.2011.236. Epub 2011 Aug 11. J Invest Dermatol. 2012. PMID: 21833020 Free PMC article.
In contrast, CD4 single-positive thymocytes and peripheral T cells develop in the absence of GILT or TRP1, demonstrating that GILT is required for negative selection of TRP1-specific thymocytes. Although TRP1-specific T cells escape thymic deletion in the absence of …
In contrast, CD4 single-positive thymocytes and peripheral T cells develop in the absence of GILT or TRP1, demonstrating that GILT …
101 results