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Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-κB activation in murine macrophages via changes in intracellular calcium.
Diwakar BT, Yoast R, Nettleford S, Qian F, Lee TJ, Berry S, Huffnagle I, Rossi RM, Trebak M, Paulson RF, Prabhu KS. Diwakar BT, et al. FASEB J. 2019 Nov;33(11):12838-12852. doi: 10.1096/fj.201802608R. Epub 2019 Sep 13. FASEB J. 2019. PMID: 31518163 Free PMC article.
We investigated the regulation of LPS or zymosan-induced inflammatory response by signals from the Crth2 receptor in macrophages that lack Crth2 expression [knockout (KO)]. Increased expression of proinflammatory genes, including Tnf-alpha, was observed in Crth2 KO …
We investigated the regulation of LPS or zymosan-induced inflammatory response by signals from the Crth2 receptor in macrophages that lack C …