Antidiabetic Effects of Tea

Qiu-Yue Fu; Qing-Sheng Li; Xiao-Ming Lin; Ru-Ying Qiao; Rui Yang; Xu-Min Li; Zhan-Bo Dong; Li-Ping Xiang; Xin-Qiang Zheng; Jian-Liang Lu; Cong-Bo Yuan; Jian-Hui Ye; Yue-Rong Liang

doi:10.3390/molecules22050849

Antidiabetic Effects of Tea

Molecules. 2017 May 20;22(5):849. doi: 10.3390/molecules22050849.

Authors

Qiu-Yue Fu¹, Qing-Sheng Li², Xiao-Ming Lin³, Ru-Ying Qiao⁴, Rui Yang⁵, Xu-Min Li⁶, Zhan-Bo Dong⁷, Li-Ping Xiang⁸, Xin-Qiang Zheng⁹, Jian-Liang Lu¹⁰, Cong-Bo Yuan¹¹, Jian-Hui Ye¹², Yue-Rong Liang¹³

Affiliations

¹ Tea Research Institute, Zhejiang University, Hangzhou 310058, China. 21516103@zju.edu.cn.
² Tea Research Institute, Zhejiang University, Hangzhou 310058, China. qsli@zju.edu.cn.
³ Tea Research Institute, Zhejiang University, Hangzhou 310058, China. 21516097@zju.edu.cn.
⁴ Tea Research Institute, Zhejiang University, Hangzhou 310058, China. ryqiao@zju.edu.cn.
⁵ Tea Research Institute, Zhejiang University, Hangzhou 310058, China. kexiaonao@163.com.
⁶ Tea Research Institute, Zhejiang University, Hangzhou 310058, China. 21616096@zju.edu.cn.
⁷ Wenzhou Vocational College of Science and Technology, Wenzhou 325035, China. dozhanbo@gmail.com.
⁸ National Tea and Tea product Quality Supervision and Inspection Center (Guizhou), Zunyi 563100, China. gzzyzj_2009@vip.sina.com.
⁹ Tea Research Institute, Zhejiang University, Hangzhou 310058, China. xqzheng@zju.edu.cn.
¹⁰ Tea Research Institute, Zhejiang University, Hangzhou 310058, China. jllu@zju.edu.cn.
¹¹ Yuyuanchun Tea Limited, Jufeng Town, Rizhao 276812, China. yuyuanchun@126.com.
¹² Tea Research Institute, Zhejiang University, Hangzhou 310058, China. jianhuiye@zju.edu.cn.
¹³ Tea Research Institute, Zhejiang University, Hangzhou 310058, China. yrliang@zju.edu.cn.

Abstract

Diabetes mellitus (DM) is a chronic endocrine disease resulted from insulin secretory defect or insulin resistance and it is a leading cause of death around the world. The care of DM patients consumes a huge budget due to the high frequency of consultations and long hospitalizations, making DM a serious threat to both human health and global economies. Tea contains abundant polyphenols and caffeine which showed antidiabetic activity, so the development of antidiabetic medications from tea and its extracts is increasingly receiving attention. However, the results claiming an association between tea consumption and reduced DM risk are inconsistent. The advances in the epidemiologic evidence and the underlying antidiabetic mechanisms of tea are reviewed in this paper. The inconsistent results and the possible causes behind them are also discussed.

Keywords: Camellia sinensis; caffeine; diabetes mellitus; epidemiological analysis; tea catechins; tea polysaccharides.

Publication types

Review

MeSH terms

Animals
Caffeine / chemistry
Caffeine / isolation & purification
Caffeine / pharmacology
Camellia sinensis / chemistry*
Catechin / chemistry
Catechin / isolation & purification
Catechin / pharmacology*
Diabetes Mellitus / diet therapy*
Diabetes Mellitus / epidemiology
Diabetes Mellitus / metabolism
Diabetes Mellitus / physiopathology
Diabetes Mellitus, Experimental / diet therapy
Diabetes Mellitus, Experimental / metabolism
Diabetes Mellitus, Experimental / physiopathology
Epidemiologic Studies
Flavonoids / chemistry
Flavonoids / isolation & purification
Flavonoids / pharmacology
Gene Expression Regulation / drug effects
Glucose Transport Proteins, Facilitative / antagonists & inhibitors
Glucose Transport Proteins, Facilitative / genetics
Glucose Transport Proteins, Facilitative / metabolism
Humans
Hypoglycemic Agents / chemistry
Hypoglycemic Agents / isolation & purification
Hypoglycemic Agents / pharmacology*
Insulin Resistance
Polyphenols / chemistry
Polyphenols / isolation & purification
Polyphenols / pharmacology*
Tea / chemistry*

Substances

Flavonoids
Glucose Transport Proteins, Facilitative
Hypoglycemic Agents
Polyphenols
Tea
Caffeine
Catechin