Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism.
Bussi C, Heunis T, Pellegrino E, Bernard EM, Bah N, Dos Santos MS, Santucci P, Aylan B, Rodgers A, Fearns A, Mitschke J, Moore C, MacRae JI, Greco M, Reinheckel T, Trost M, Gutierrez MG.
Bussi C, et al.
Nat Commun. 2022 Nov 28;13(1):7338. doi: 10.1038/s41467-022-34632-8.
Nat Commun. 2022.
PMID: 36443305
Free PMC article.
Whether limited leakage of lysosomal contents into the cytosol affects the function of cytoplasmic organelles is unknown. Here, we show that sterile and non-sterile lysosomal damage triggers a cell death independent proteolytic remodelling of the mitochondrial prote …
Whether limited leakage of lysosomal contents into the cytosol affects the function of cytoplasmic organelles is unknown. Here, we show that …