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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1973 1
1978 2
1979 2
1982 2
1984 2
1986 2
1990 1
1991 7
1992 1
1993 3
1994 2
1995 3
1996 3
1997 3
1998 1
1999 4
2000 3
2001 6
2002 6
2003 8
2004 13
2005 18
2006 17
2007 14
2008 16
2009 16
2010 23
2011 29
2012 40
2013 36
2014 47
2015 40
2016 58
2017 59
2018 69
2019 70
2020 79
2021 105
2022 103
2023 101
2024 39

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914 results

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The following term was not found in PubMed: Claudemir
Page 1
Targeting Tumor Microenvironment for Cancer Therapy.
Roma-Rodrigues C, Mendes R, Baptista PV, Fernandes AR. Roma-Rodrigues C, et al. Int J Mol Sci. 2019 Feb 15;20(4):840. doi: 10.3390/ijms20040840. Int J Mol Sci. 2019. PMID: 30781344 Free PMC article. Review.
These events create hypoxia, oxidative stress and acidosis within the TME triggering an adjustment of the extracellular matrix (ECM), a response from neighbor stromal cells (e.g., fibroblasts) and immune cells (lymphocytes and macrophages), inducing angiogenesis and, ultim …
These events create hypoxia, oxidative stress and acidosis within the TME triggering an adjustment of the extracellular matrix (ECM), a resp …
Proceedings of the 3rd IPLeiria's International Health Congress : Leiria, Portugal. 6-7 May 2016.
Tomás CC, Oliveira E, Sousa D, Uba-Chupel M, Furtado G, Rocha C, Teixeira A, Ferreira P, Alves C, Gisin S, Catarino E, Carvalho N, Coucelo T, Bonfim L, Silva C, Franco D, González JA, Jardim HG, Silva R, Baixinho CL, Presado MªH, Marques MªF, Cardoso ME, Cunha M, Mendes J, Xavier A, Galhardo A, Couto M, Frade JG, Nunes C, Mesquita JR, Nascimento MS, Gonçalves G, Castro C, Mártires A, Monteiro MªJ, Rainho C, Caballero FP, Monago FM, Guerrero JT, Monago RM, Trigo AP, Gutierrez ML, Milanés GM, Reina MG, Villanueva AG, Piñero AS, Aliseda IR, Ramirez FB, Ribeiro A, Quelhas A, Manso C, Caballero FP, Guerrero JT, Monago FM, Santos RB, Jimenez NR, Nuñez CG, Gomez IR, Fernandez MªJL, Marquez LA, Moreno AL, Huertas MªJT, Ramirez FB, Seabra D, Salvador MªC, Braga L, Parreira P, Salgueiro-Oliveira A, Arreguy-Sena C, Oliveira BF, Henriques MªA, Santos J, Lebre S, Marques A, Festas C, Rodrigues S, Ribeiro A, Lumini J, Figueiredo AG, Hernandez-Martinez FJ, Campi L, Quintana-Montesdeoca MªP, Jimenez-Diaz JF, Rodriguez-De-Vera BC, Parente A, Mata MªA, Pereira AMª, Fernandes A, Brás M, Pinto MªR, Parreira P, Basto ML, Rei AC, Mónico LM, Sousa G, Morna C, Freitas O, Freitas G, Jardim A, Vasconcelos … See abstract for full author list ➔ Tomás CC, et al. BMC Health Serv Res. 2016 Jul 6;16 Suppl 3(Suppl 3):200. doi: 10.1186/s12913-016-1423-5. BMC Health Serv Res. 2016. PMID: 27409075 Free PMC article.
Cardoso O3 Negative childhood experiences and fears of compassion: Implications for psychological difficulties in adolescence Marina Cunha, Joana Mendes, Ana Xavier, Ana Galhardo, Margarida Couto O4 Optimal age to give the first dose of measles vaccine in Portugal Joao …
Cardoso O3 Negative childhood experiences and fears of compassion: Implications for psychological difficulties in adolescence Marina Cunha, …
G-Quadruplexes in c-MYC Promoter as Targets for Cancer Therapy.
Bahls B, Aljnadi IM, Emídio R, Mendes E, Paulo A. Bahls B, et al. Biomedicines. 2023 Mar 21;11(3):969. doi: 10.3390/biomedicines11030969. Biomedicines. 2023. PMID: 36979947 Free PMC article. Review.
Meanwhile, another approach has been explored since the discovery that G-quadruplex secondary DNA structures formed in the guanine-rich sequences of the c-MYC promoter region can downregulate the transcription of this oncogene. Here, we will overview the major achievements …
Meanwhile, another approach has been explored since the discovery that G-quadruplex secondary DNA structures formed in the guanine-ri …
Fluids in ARDS: more pros than cons.
Mendes RS, Pelosi P, Schultz MJ, Rocco PRM, Silva PL. Mendes RS, et al. Intensive Care Med Exp. 2020 Dec 18;8(Suppl 1):32. doi: 10.1186/s40635-020-00319-x. Intensive Care Med Exp. 2020. PMID: 33336259 Free PMC article. Review.
Indoloquinolines as scaffolds for the design of potent G-quadruplex ligands.
Mendes E, Bahls B, Aljnadi IM, Paulo A. Mendes E, et al. Bioorg Med Chem Lett. 2022 Sep 15;72:128862. doi: 10.1016/j.bmcl.2022.128862. Epub 2022 Jun 15. Bioorg Med Chem Lett. 2022. PMID: 35716866 Review.
Herein we review the indoloquinolines and bioisosters that have been designed, synthesised, and evaluated for their selective binding to G-quadruplex nucleic acid structures, as well as the reported effects in cancer cells. The data collected so far strongly suggest that i …
Herein we review the indoloquinolines and bioisosters that have been designed, synthesised, and evaluated for their selective binding to …
The two sides of a lipid-protein story.
Basso LGM, Mendes LFS, Costa-Filho AJ. Basso LGM, et al. Biophys Rev. 2016 Jun;8(2):179-191. doi: 10.1007/s12551-016-0199-5. Epub 2016 Apr 30. Biophys Rev. 2016. PMID: 28510056 Free PMC article. Review.
Animal Models to Study Cancer and Its Microenvironment.
Mendes N, Dias Carvalho P, Martins F, Mendonça S, Malheiro AR, Ribeiro A, Carvalho J, Velho S. Mendes N, et al. Adv Exp Med Biol. 2020;1219:389-401. doi: 10.1007/978-3-030-34025-4_20. Adv Exp Med Biol. 2020. PMID: 32130710 Review.
Therefore, a better understanding of the tumorigenic processes implies the combined study of the cancer cell and the biologic, chemical and mechanic constituents of the tumor microenvironment, as their concerted action plays a major role in the carcinogenic pathway and is a key d …
Therefore, a better understanding of the tumorigenic processes implies the combined study of the cancer cell and the biologic, chemical and …
Major Achievements in the Design of Quadruplex-Interactive Small Molecules.
Mendes E, Aljnadi IM, Bahls B, Victor BL, Paulo A. Mendes E, et al. Pharmaceuticals (Basel). 2022 Feb 28;15(3):300. doi: 10.3390/ph15030300. Pharmaceuticals (Basel). 2022. PMID: 35337098 Free PMC article. Review.
Organic small molecules that can recognize and bind to G-quadruplex and i-Motif nucleic acids have great potential as selective drugs or as tools in drug target discovery programs, or even in the development of nanodevices for medical diagnosis. ...
Organic small molecules that can recognize and bind to G-quadruplex and i-Motif nucleic acids have great potential as selective drugs …
Cashew Nut Allergy: Clinical Relevance and Allergen Characterisation.
Mendes C, Costa J, Vicente AA, Oliveira MBPP, Mafra I. Mendes C, et al. Clin Rev Allergy Immunol. 2019 Aug;57(1):1-22. doi: 10.1007/s12016-016-8580-5. Clin Rev Allergy Immunol. 2019. PMID: 27585580 Review.
However, cashew nut is also classified as a potent allergenic food known to be responsible for triggering severe and systemic immune reactions (e.g. anaphylaxis) in sensitised/allergic individuals that often demand epinephrine treatment and hospitalisation. ...
However, cashew nut is also classified as a potent allergenic food known to be responsible for triggering severe and systemic immune reactio …
914 results