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Isocitrate dehydrogenase 1 sustains a hybrid cytoplasmic-mitochondrial tricarboxylic acid cycle that can be targeted for therapeutic purposes in prostate cancer.
Gonthier K, Weidmann C, Berthiaume L, Jobin C, Lacouture A, Lafront C, Harvey M, Neveu B, Loehr J, Bergeron A, Fradet Y, Lacombe L, Riopel J, Latulippe É, Atallah C, Shum M, Lambert JP, Pouliot F, Pelletier M, Audet-Walsh É. Gonthier K, et al. Among authors: weidmann c. Mol Oncol. 2023 Oct;17(10):2109-2125. doi: 10.1002/1878-0261.13441. Epub 2023 Jul 19. Mol Oncol. 2023. PMID: 37086156 Free PMC article.
The estrogen signaling pathway reprograms prostate cancer cell metabolism and supports proliferation and disease progression.
Lafront C, Germain L, Campolina-Silva GH, Weidmann C, Berthiaume L, Hovington H, Brisson H, Jobin C, Frégeau-Proulx L, Cotau R, Gonthier K, Lacouture A, Caron P, Ménard C, Atallah C, Riopel J, Latulippe É, Bergeron A, Toren P, Guillemette C, Pelletier M, Fradet Y, Belleannée C, Pouliot F, Lacombe L, Lévesque É, Audet-Walsh É. Lafront C, et al. Among authors: weidmann c. J Clin Invest. 2024 Apr 16:e170809. doi: 10.1172/JCI170809. Online ahead of print. J Clin Invest. 2024. PMID: 38625747 Free article.
KLF5 and NFYA factors as novel regulators of prostate cancer cell metabolism.
Poluri RTK, Paquette V, Allain ÉP, Lafront C, Joly-Beauparlant C, Weidmann C, Droit A, Guillemette C, Pelletier M, Audet-Walsh É. Poluri RTK, et al. Among authors: weidmann c. Endocr Relat Cancer. 2021 Apr;28(4):257-271. doi: 10.1530/ERC-20-0504. Endocr Relat Cancer. 2021. PMID: 33690159
Multiple metabolic pathways fuel the truncated tricarboxylic acid cycle of the prostate to sustain constant citrate production and secretion.
Frégeau-Proulx L, Lacouture A, Berthiaume L, Weidmann C, Harvey M, Gonthier K, Pelletier JF, Neveu B, Jobin C, Bastien D, Bergeron A, Fradet Y, Lacombe L, Laverdière I, Atallah C, Pouliot F, Audet-Walsh É. Frégeau-Proulx L, et al. Among authors: weidmann c. Mol Metab. 2022 Aug;62:101516. doi: 10.1016/j.molmet.2022.101516. Epub 2022 May 20. Mol Metab. 2022. PMID: 35598879 Free PMC article.
A FACS-Free Purification Method to Study Estrogen Signaling, Organoid Formation, and Metabolic Reprogramming in Mammary Epithelial Cells.
Lacouture A, Jobin C, Weidmann C, Berthiaume L, Bastien D, Laverdière I, Pelletier M, Audet-Walsh É. Lacouture A, et al. Among authors: weidmann c. Front Endocrinol (Lausanne). 2021 Aug 12;12:672466. doi: 10.3389/fendo.2021.672466. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34456857 Free PMC article.
15 results